An Observational Cohort Study and Nested Randomized Controlled Trial on Nutrition and Growth Outcomes in Moderate and Late Preterm Infants (FLAMINGO)
Background: Over the past decades, the preterm birth rate has increased, mostly due to a rise in late and moderate preterm (LMPT, 32–36 weeks gestation) births. LMPT birth affects 6–7% of all births in the United Kingdom and is associated with increased morbidity risk after birth in infancy as well...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.561419/full |
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| author | Andreas Kakaroukas Marieke Abrahamse-Berkeveld Janet E. Berrington Janet E. Berrington Richard J. Q. McNally Christopher J. Stewart Nicholas D. Embleton Nicholas D. Embleton Ruurd M. van Elburg |
| author_facet | Andreas Kakaroukas Marieke Abrahamse-Berkeveld Janet E. Berrington Janet E. Berrington Richard J. Q. McNally Christopher J. Stewart Nicholas D. Embleton Nicholas D. Embleton Ruurd M. van Elburg |
| author_sort | Andreas Kakaroukas |
| collection | DOAJ |
| description | Background: Over the past decades, the preterm birth rate has increased, mostly due to a rise in late and moderate preterm (LMPT, 32–36 weeks gestation) births. LMPT birth affects 6–7% of all births in the United Kingdom and is associated with increased morbidity risk after birth in infancy as well as in adulthood. Early life nutrition has a critical role in determining infant growth and development, but there are limited data specifically addressing LMPT infants, which was the rationale for the design of the current study.Objective: The Feeding Late and Moderate Infants and Growth Outcomes (FLAMINGO) study aims to improve understanding of the longitudinal growth, nutritional needs, and body composition of LMPT infants as well as their microbiome development and neurodevelopment. In addition, having a nested non-inferiority trial enables evaluation of the nutritional adequacy of a concept IMF with large milk phospholipid-coated lipid droplets comprising dairy and vegetable lipids. The primary outcome of this RCT is daily weight gain until 3 months corrected age.Methods: A total of 250 healthy LMPT infants (32+0–36+6 weeks gestational age) with birth weight 1.25–3.0 kg will be recruited to the cohort, of which 140 infants are anticipated to be enrolled in the RCT. During six visits over the first 2 years of life, anthropometry, body composition (using dual energy X-Ray absorptiometry), feeding behavior, and developmental outcomes will be measured. Saliva and stool samples will be collected for oral and gut microbiota assessment.Discussion: The FLAMINGO study will improve understanding of the longitudinal growth, body composition development, and feeding characteristics of LMPT infants and gain insights into their microbiome and neurodevelopment.Study Registration:www.isrctn.com; Identifier ISRCTN15469594. |
| first_indexed | 2024-12-14T00:16:33Z |
| format | Article |
| id | doaj.art-a1dd3677423140529eac7cac9c336c87 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-14T00:16:33Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-a1dd3677423140529eac7cac9c336c872022-12-21T23:25:31ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-03-01810.3389/fnut.2021.561419561419An Observational Cohort Study and Nested Randomized Controlled Trial on Nutrition and Growth Outcomes in Moderate and Late Preterm Infants (FLAMINGO)Andreas Kakaroukas0Marieke Abrahamse-Berkeveld1Janet E. Berrington2Janet E. Berrington3Richard J. Q. McNally4Christopher J. Stewart5Nicholas D. Embleton6Nicholas D. Embleton7Ruurd M. van Elburg8Newcastle Neonatal Service, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust, Newcastle upon Tyne, United KingdomDanone Nutricia Research, Utrecht, NetherlandsNewcastle Neonatal Service, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust, Newcastle upon Tyne, United KingdomTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United KingdomFaculty of Medical Sciences, Population and Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United KingdomNewcastle Neonatal Service, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust, Newcastle upon Tyne, United KingdomFaculty of Medical Sciences, Population and Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomEmma Children's Hospital, Amsterdam University Medical Centers (Amsterdam UMC) Amsterdam, Amsterdam, NetherlandsBackground: Over the past decades, the preterm birth rate has increased, mostly due to a rise in late and moderate preterm (LMPT, 32–36 weeks gestation) births. LMPT birth affects 6–7% of all births in the United Kingdom and is associated with increased morbidity risk after birth in infancy as well as in adulthood. Early life nutrition has a critical role in determining infant growth and development, but there are limited data specifically addressing LMPT infants, which was the rationale for the design of the current study.Objective: The Feeding Late and Moderate Infants and Growth Outcomes (FLAMINGO) study aims to improve understanding of the longitudinal growth, nutritional needs, and body composition of LMPT infants as well as their microbiome development and neurodevelopment. In addition, having a nested non-inferiority trial enables evaluation of the nutritional adequacy of a concept IMF with large milk phospholipid-coated lipid droplets comprising dairy and vegetable lipids. The primary outcome of this RCT is daily weight gain until 3 months corrected age.Methods: A total of 250 healthy LMPT infants (32+0–36+6 weeks gestational age) with birth weight 1.25–3.0 kg will be recruited to the cohort, of which 140 infants are anticipated to be enrolled in the RCT. During six visits over the first 2 years of life, anthropometry, body composition (using dual energy X-Ray absorptiometry), feeding behavior, and developmental outcomes will be measured. Saliva and stool samples will be collected for oral and gut microbiota assessment.Discussion: The FLAMINGO study will improve understanding of the longitudinal growth, body composition development, and feeding characteristics of LMPT infants and gain insights into their microbiome and neurodevelopment.Study Registration:www.isrctn.com; Identifier ISRCTN15469594.https://www.frontiersin.org/articles/10.3389/fnut.2021.561419/fullprematuritylate pretermmoderate pretermgrowthnutritionbreastfeeding |
| spellingShingle | Andreas Kakaroukas Marieke Abrahamse-Berkeveld Janet E. Berrington Janet E. Berrington Richard J. Q. McNally Christopher J. Stewart Nicholas D. Embleton Nicholas D. Embleton Ruurd M. van Elburg An Observational Cohort Study and Nested Randomized Controlled Trial on Nutrition and Growth Outcomes in Moderate and Late Preterm Infants (FLAMINGO) Frontiers in Nutrition prematurity late preterm moderate preterm growth nutrition breastfeeding |
| title | An Observational Cohort Study and Nested Randomized Controlled Trial on Nutrition and Growth Outcomes in Moderate and Late Preterm Infants (FLAMINGO) |
| title_full | An Observational Cohort Study and Nested Randomized Controlled Trial on Nutrition and Growth Outcomes in Moderate and Late Preterm Infants (FLAMINGO) |
| title_fullStr | An Observational Cohort Study and Nested Randomized Controlled Trial on Nutrition and Growth Outcomes in Moderate and Late Preterm Infants (FLAMINGO) |
| title_full_unstemmed | An Observational Cohort Study and Nested Randomized Controlled Trial on Nutrition and Growth Outcomes in Moderate and Late Preterm Infants (FLAMINGO) |
| title_short | An Observational Cohort Study and Nested Randomized Controlled Trial on Nutrition and Growth Outcomes in Moderate and Late Preterm Infants (FLAMINGO) |
| title_sort | observational cohort study and nested randomized controlled trial on nutrition and growth outcomes in moderate and late preterm infants flamingo |
| topic | prematurity late preterm moderate preterm growth nutrition breastfeeding |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.561419/full |
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