Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location Prediction
Cancer is a complex group of diseases which arises from uncontrolled growth and spread of abnormal cells in the body. The pathophysiology of cancer involves a sequence of events at the cellular and molecular levels, often initiated by genetic mutations or alterations. These mutations can be acquired...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2023-10-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://actamedindones.org/index.php/ijim/article/view/2668 |
| _version_ | 1797355230286839808 |
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| author | Ikhwan Rinaldi |
| author_facet | Ikhwan Rinaldi |
| author_sort | Ikhwan Rinaldi |
| collection | DOAJ |
| description | Cancer is a complex group of diseases which arises from uncontrolled growth and spread of abnormal cells in the body. The pathophysiology of cancer involves a sequence of events at the cellular and molecular levels, often initiated by genetic mutations or alterations. These mutations can be acquired due to various factors like environmental exposures such as from carcinogens, lifestyle choices, or inherited genetic conditions. When a cell’s DNA is damaged or mutated, it can disrupt the normal regulatory mechanisms that control cell division and apoptosis, leading to uncontrolled proliferation and cancer.
the intricate interplay between genetic mutations, angiogenesis, hematogenic spread, CTCs, immune cells, and systemic cancer therapy defines the complex landscape of cancer progression and treatment. Understanding the role of immune cells, particularly Tregs marked by FOXP3, as prognostic markers in various cancers, alongside advancements in cancer diagnosis involving CTCs, holds promise in understanding cancer prognosis and improving cancer management. Moreover, ongoing research into alleviating chemotherapy-induced side effects, like HFS offer avenues for improving patient care and treatment outcomes in cancer management. |
| first_indexed | 2024-03-08T14:08:15Z |
| format | Article |
| id | doaj.art-a1dfa043b5b24cbd86b80208a82991ed |
| institution | Directory Open Access Journal |
| issn | 0125-9326 2338-2732 |
| language | English |
| last_indexed | 2024-03-08T14:08:15Z |
| publishDate | 2023-10-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj.art-a1dfa043b5b24cbd86b80208a82991ed2024-01-15T04:28:05ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322023-10-01554634Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location PredictionIkhwan Rinaldi0Division of Hematology and Medical Oncology, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia –Cipto Mangunkusumo Hospital, Jakarta, IndonesiaCancer is a complex group of diseases which arises from uncontrolled growth and spread of abnormal cells in the body. The pathophysiology of cancer involves a sequence of events at the cellular and molecular levels, often initiated by genetic mutations or alterations. These mutations can be acquired due to various factors like environmental exposures such as from carcinogens, lifestyle choices, or inherited genetic conditions. When a cell’s DNA is damaged or mutated, it can disrupt the normal regulatory mechanisms that control cell division and apoptosis, leading to uncontrolled proliferation and cancer. the intricate interplay between genetic mutations, angiogenesis, hematogenic spread, CTCs, immune cells, and systemic cancer therapy defines the complex landscape of cancer progression and treatment. Understanding the role of immune cells, particularly Tregs marked by FOXP3, as prognostic markers in various cancers, alongside advancements in cancer diagnosis involving CTCs, holds promise in understanding cancer prognosis and improving cancer management. Moreover, ongoing research into alleviating chemotherapy-induced side effects, like HFS offer avenues for improving patient care and treatment outcomes in cancer management.https://actamedindones.org/index.php/ijim/article/view/2668tumour cellfoxp3t-cellscancercirculating tumour cell (ctc) |
| spellingShingle | Ikhwan Rinaldi Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location Prediction Acta Medica Indonesiana tumour cell foxp3 t-cells cancer circulating tumour cell (ctc) |
| title | Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location Prediction |
| title_full | Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location Prediction |
| title_fullStr | Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location Prediction |
| title_full_unstemmed | Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location Prediction |
| title_short | Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location Prediction |
| title_sort | circulating tumour cells and foxp3 in regulatory t cells as new modalities in cancer diagnosis and metastasis location prediction |
| topic | tumour cell foxp3 t-cells cancer circulating tumour cell (ctc) |
| url | https://actamedindones.org/index.php/ijim/article/view/2668 |
| work_keys_str_mv | AT ikhwanrinaldi circulatingtumourcellsandfoxp3inregulatorytcellsasnewmodalitiesincancerdiagnosisandmetastasislocationprediction |