Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D
Abstract Background Liver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D has gone beyond its role in skeletal disorders by showcasing its associa...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-02-01
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| Series: | Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12986-018-0251-5 |
| _version_ | 1811271789094895616 |
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| author | Shahida Khan Ashraf Ali Sarah Khan Ahmed Bakillah Ghazi Damanhouri Aziz Khan Ahmed Makki Ibtehal AlAnsari Naheed Banu |
| author_facet | Shahida Khan Ashraf Ali Sarah Khan Ahmed Bakillah Ghazi Damanhouri Aziz Khan Ahmed Makki Ibtehal AlAnsari Naheed Banu |
| author_sort | Shahida Khan |
| collection | DOAJ |
| description | Abstract Background Liver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D has gone beyond its role in skeletal disorders by showcasing its associations in other metabolic dysfunctions too. Result Epidemiological evidences show a correlation between the status of vitamin D and different forms of cancer. Vitamin D receptors and alterations in gene expression appear decisive in the development of chronic liver disorders. Nutritional status therefore plays a significant role in avoiding the complications related to liver dysfunctions, making it mandatory in maintaining vitamin D sufficiency in the body. Therapies with omega-3 fatty acids, antioxidants, amino acids, steroids also render benefits which could be further explored. Recent research on the progression of certain forms of liver cancer using vitamin D analogs like Seocalcitol EB 1089 has shown good promise. Conclusion The anti-inflammatory and immuno- regulatory properties of vitamin D makes its analogs, suitable candidates of better choice for the prevention and treatment of liver disorders and cancer. |
| first_indexed | 2024-04-12T22:27:28Z |
| format | Article |
| id | doaj.art-a1dfcfb612384f42ba3a87d137d3a0d0 |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-04-12T22:27:28Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-a1dfcfb612384f42ba3a87d137d3a0d02022-12-22T03:14:04ZengBMCNutrition & Metabolism1743-70752018-02-0115111810.1186/s12986-018-0251-5Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin DShahida Khan0Ashraf Ali1Sarah Khan2Ahmed Bakillah3Ghazi Damanhouri4Aziz Khan5Ahmed Makki6Ibtehal AlAnsari7Naheed Banu8Applied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz UniversityApplied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz UniversityNational Brain Research CenterDepartment of Medicine, SUNY Downstate Medical CenterApplied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz UniversityApplied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz UniversityApplied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz UniversityApplied Nutrition and Natural Products Group, King Fahd Medical Research Center, King Abdulaziz UniversityDepartment of Biochemistry, College of Medical Rehabilitation, Buraydah, Qassim UniversityAbstract Background Liver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D has gone beyond its role in skeletal disorders by showcasing its associations in other metabolic dysfunctions too. Result Epidemiological evidences show a correlation between the status of vitamin D and different forms of cancer. Vitamin D receptors and alterations in gene expression appear decisive in the development of chronic liver disorders. Nutritional status therefore plays a significant role in avoiding the complications related to liver dysfunctions, making it mandatory in maintaining vitamin D sufficiency in the body. Therapies with omega-3 fatty acids, antioxidants, amino acids, steroids also render benefits which could be further explored. Recent research on the progression of certain forms of liver cancer using vitamin D analogs like Seocalcitol EB 1089 has shown good promise. Conclusion The anti-inflammatory and immuno- regulatory properties of vitamin D makes its analogs, suitable candidates of better choice for the prevention and treatment of liver disorders and cancer.http://link.springer.com/article/10.1186/s12986-018-0251-5Vitamin DLiver disordersAnti-inflammatoryCurrent therapies |
| spellingShingle | Shahida Khan Ashraf Ali Sarah Khan Ahmed Bakillah Ghazi Damanhouri Aziz Khan Ahmed Makki Ibtehal AlAnsari Naheed Banu Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D Nutrition & Metabolism Vitamin D Liver disorders Anti-inflammatory Current therapies |
| title | Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D |
| title_full | Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D |
| title_fullStr | Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D |
| title_full_unstemmed | Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D |
| title_short | Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D |
| title_sort | current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin d |
| topic | Vitamin D Liver disorders Anti-inflammatory Current therapies |
| url | http://link.springer.com/article/10.1186/s12986-018-0251-5 |
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