Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection Fraction
Vitamin D emerged as an important prognostic biomarker in heart failure (HF), with currently highly debated therapeutic implications. Several trials on vitamin D supplementation in HF showed improvements in left ventricular (LV) remodeling and function and health-related quality of life (HRQoL), whi...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/11/1578 |
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| author | Timea Magdolna Szabo Előd Ernő Nagy Ádám Kirchmaier Erhard Heidenhoffer Hunor-László Gábor-Kelemen Marius Frăsineanu Judit Cseke Márta Germán-Salló Attila Frigy |
| author_facet | Timea Magdolna Szabo Előd Ernő Nagy Ádám Kirchmaier Erhard Heidenhoffer Hunor-László Gábor-Kelemen Marius Frăsineanu Judit Cseke Márta Germán-Salló Attila Frigy |
| author_sort | Timea Magdolna Szabo |
| collection | DOAJ |
| description | Vitamin D emerged as an important prognostic biomarker in heart failure (HF), with currently highly debated therapeutic implications. Several trials on vitamin D supplementation in HF showed improvements in left ventricular (LV) remodeling and function and health-related quality of life (HRQoL), which did not translate into mid- to long-term beneficial effects regarding physical performance and mortality. We addressed total 25-hydroxyvitamin D (25(OH)D), serum albumin, and uric acid (UA) levels, focusing mainly on vitamin D deficiency, as potential markers of LV systolic dysfunction in HF with reduced and mildly reduced ejection fraction (HFrEF, HFmrEF). Seventy patients with LVEF < 50% were comprehensively evaluated using ECG, echocardiography, lung ultrasound (LUS), blood sampling, and the six-minute walk test (6MWT). HRQoL was also assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Statistically significant positive correlations were found between LVEF, 25(OH)D, serum UA, and albumin, respectively (<i>p</i> = 0.008, <i>p</i> = 0.009, and <i>p</i> = 0.001). Serum UA (7.4 ± 2.4 vs. 5.7 ± 2.1, <i>p</i> = 0.005), NT-proBNP levels (1090.4 (675.2–2664.9) vs. 759.0 (260.3–1474.8), <i>p</i> = 0.034), and MLHFQ scores (21.0 (14.0–47.0) vs. 14.5 (4.5–25.5), <i>p</i> = 0.012) were significantly higher, whereas 25(OH)D concentrations (17.6 (15.1–28.2) vs. 22.7 (19.5–33.8), <i>p</i> = 0.010) were lower in subjects with severely reduced LVEF. Also, 25(OH)D was independently associated with LVEF in univariate and multiple regression analysis, maintaining its significance even after adjusting for confounders such as age, NT-proBNP, the presence of chronic coronary syndrome, hypertension, and anemia. According to our current findings, 25(OH)D is closely associated with LVEF, further supporting the need to establish correct vitamin D supplementation schemes and dietary interventions in HF. The changes in LVEF, 25(OH)D, serum UA, and albumin levels in HFrEF and HFmrEF indicate a similar pathophysiological background. |
| first_indexed | 2024-03-09T16:59:37Z |
| format | Article |
| id | doaj.art-a1e01bb6bb1a4b2d905fb47d18a18ddc |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T16:59:37Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-a1e01bb6bb1a4b2d905fb47d18a18ddc2023-11-24T14:31:48ZengMDPI AGBiomolecules2218-273X2023-10-011311157810.3390/biom13111578Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection FractionTimea Magdolna Szabo0Előd Ernő Nagy1Ádám Kirchmaier2Erhard Heidenhoffer3Hunor-László Gábor-Kelemen4Marius Frăsineanu5Judit Cseke6Márta Germán-Salló7Attila Frigy8Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, RomaniaDepartment of Biochemistry and Environmental Chemistry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, RomaniaDepartment of Cardiology, Clinical County Hospital Mureș, 540103 Târgu Mureș, RomaniaDepartment of Cardiology, Clinical County Hospital Mureș, 540103 Târgu Mureș, RomaniaDepartment of Cardiology, Clinical County Hospital Mureș, 540103 Târgu Mureș, RomaniaDepartment of Cardiology, Clinical County Hospital Mureș, 540103 Târgu Mureș, RomaniaDepartment of Cardiology, Clinical County Hospital Mureș, 540103 Târgu Mureș, RomaniaDepartment of Internal Medicine III, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, RomaniaDepartment of Cardiology, Clinical County Hospital Mureș, 540103 Târgu Mureș, RomaniaVitamin D emerged as an important prognostic biomarker in heart failure (HF), with currently highly debated therapeutic implications. Several trials on vitamin D supplementation in HF showed improvements in left ventricular (LV) remodeling and function and health-related quality of life (HRQoL), which did not translate into mid- to long-term beneficial effects regarding physical performance and mortality. We addressed total 25-hydroxyvitamin D (25(OH)D), serum albumin, and uric acid (UA) levels, focusing mainly on vitamin D deficiency, as potential markers of LV systolic dysfunction in HF with reduced and mildly reduced ejection fraction (HFrEF, HFmrEF). Seventy patients with LVEF < 50% were comprehensively evaluated using ECG, echocardiography, lung ultrasound (LUS), blood sampling, and the six-minute walk test (6MWT). HRQoL was also assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Statistically significant positive correlations were found between LVEF, 25(OH)D, serum UA, and albumin, respectively (<i>p</i> = 0.008, <i>p</i> = 0.009, and <i>p</i> = 0.001). Serum UA (7.4 ± 2.4 vs. 5.7 ± 2.1, <i>p</i> = 0.005), NT-proBNP levels (1090.4 (675.2–2664.9) vs. 759.0 (260.3–1474.8), <i>p</i> = 0.034), and MLHFQ scores (21.0 (14.0–47.0) vs. 14.5 (4.5–25.5), <i>p</i> = 0.012) were significantly higher, whereas 25(OH)D concentrations (17.6 (15.1–28.2) vs. 22.7 (19.5–33.8), <i>p</i> = 0.010) were lower in subjects with severely reduced LVEF. Also, 25(OH)D was independently associated with LVEF in univariate and multiple regression analysis, maintaining its significance even after adjusting for confounders such as age, NT-proBNP, the presence of chronic coronary syndrome, hypertension, and anemia. According to our current findings, 25(OH)D is closely associated with LVEF, further supporting the need to establish correct vitamin D supplementation schemes and dietary interventions in HF. The changes in LVEF, 25(OH)D, serum UA, and albumin levels in HFrEF and HFmrEF indicate a similar pathophysiological background.https://www.mdpi.com/2218-273X/13/11/1578heart failureheart failure with reduced ejection fractionheart failure with mildly reduced ejection fractionvitamin D deficiencyserum albuminserum uric acid |
| spellingShingle | Timea Magdolna Szabo Előd Ernő Nagy Ádám Kirchmaier Erhard Heidenhoffer Hunor-László Gábor-Kelemen Marius Frăsineanu Judit Cseke Márta Germán-Salló Attila Frigy Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection Fraction Biomolecules heart failure heart failure with reduced ejection fraction heart failure with mildly reduced ejection fraction vitamin D deficiency serum albumin serum uric acid |
| title | Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection Fraction |
| title_full | Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection Fraction |
| title_fullStr | Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection Fraction |
| title_full_unstemmed | Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection Fraction |
| title_short | Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection Fraction |
| title_sort | total 25 hydroxyvitamin d is an independent marker of left ventricular ejection fraction in heart failure with reduced and mildly reduced ejection fraction |
| topic | heart failure heart failure with reduced ejection fraction heart failure with mildly reduced ejection fraction vitamin D deficiency serum albumin serum uric acid |
| url | https://www.mdpi.com/2218-273X/13/11/1578 |
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