Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection

Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection

ABSTRACT From various screens, we found that Kaposi’s sarcoma-associated herpesvirus (KSHV) viral microRNAs (miRNAs) target several enzymes in the mevalonate/cholesterol pathway. 3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase 1 (HMGCS1), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR [a rate-...

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Bibliographic Details
Main Authors: Anna K. P. Serquiña, Diane M. Kambach, Ontara Sarker, Joseph M. Ziegelbauer
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
Kaposi's sarcoma-associated herpesvirus
cholesterol
human herpesviruses
microRNA
Online Access:https://journals.asm.org/doi/10.1128/mBio.00576-17

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