Long-Term Survival Effect of the Interval between Postoperative Chemotherapy and Radiotherapy in Patients with Completely Resected Pathological N2 Non-Small-Cell Lung Cancer
(1) Purpose: To investigate the effects of the time interval between initiation of adjuvant chemotherapy and radiotherapy on survival outcomes in patients with completely resected stage IIIA pN2 non-small-cell lung cancer (NSCLC); (2) Methods: Data on 2515 patients with completely resected stage III...
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MDPI AG
2021-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/10/2494 |
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| author | Shih-Min Lin Hsiu-Ying Ku Che-Yu Hsu Chih-Liang Wang Gee-Chen Chang Cheng-Shyong Chang Tsang-Wu Liu |
| author_facet | Shih-Min Lin Hsiu-Ying Ku Che-Yu Hsu Chih-Liang Wang Gee-Chen Chang Cheng-Shyong Chang Tsang-Wu Liu |
| author_sort | Shih-Min Lin |
| collection | DOAJ |
| description | (1) Purpose: To investigate the effects of the time interval between initiation of adjuvant chemotherapy and radiotherapy on survival outcomes in patients with completely resected stage IIIA pN2 non-small-cell lung cancer (NSCLC); (2) Methods: Data on 2515 patients with completely resected stage IIIA pN2 NSCLC in 2007–2017 were extracted from the Taiwan Cancer Registry Database. The survival outcomes in patients who underwent concurrent chemoradiotherapy (CCRT) and sequential chemotherapy and radiotherapy (SCRT) with either a short (SCRT1) or long (SCRT2) interval between treatments were estimated using Kaplan–Meier, Cox regression, and propensity score matching (PSM); (3) Results: Multivariate analyses of OS showed that SCRT2 (hazard ratio [HR] 0.64, <i>p</i> = 0.017) was associated with improved overall survival (OS). After PSM, the median OS periods were 64 and 75 months in the SCRT1 and SCRT2 groups, respectively, which differed significantly from that of 58 months in the CCRT group (<i>p</i> = 0.003). In elderly patients, SCRT2 significantly improved survival relative to CCRT before PSM (<i>p</i> = 0.024) and after PSM (<i>p</i> = 0.002); (4) Conclusions: A longer interval between initiation of adjuvant chemotherapy and postoperative radiotherapy (PORT; SCRT2) improved OS relative to CCRT; the benefits were greater in elderly patients (age >60 years). |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T11:14:25Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a1e3835c55e549d58c540cc15a28f6882023-11-21T20:34:07ZengMDPI AGCancers2072-66942021-05-011310249410.3390/cancers13102494Long-Term Survival Effect of the Interval between Postoperative Chemotherapy and Radiotherapy in Patients with Completely Resected Pathological N2 Non-Small-Cell Lung CancerShih-Min Lin0Hsiu-Ying Ku1Che-Yu Hsu2Chih-Liang Wang3Gee-Chen Chang4Cheng-Shyong Chang5Tsang-Wu Liu6Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanNational Institute of Cancer Research, National Health Research Institute, Miaoli 350, TaiwanDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanSchool of Medicine and Institute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDivision of Hematology and Oncology, Chang Bing Show Chwan Memorial Hospital, Changhua 505, TaiwanNational Institute of Cancer Research, National Health Research Institute, Miaoli 350, Taiwan(1) Purpose: To investigate the effects of the time interval between initiation of adjuvant chemotherapy and radiotherapy on survival outcomes in patients with completely resected stage IIIA pN2 non-small-cell lung cancer (NSCLC); (2) Methods: Data on 2515 patients with completely resected stage IIIA pN2 NSCLC in 2007–2017 were extracted from the Taiwan Cancer Registry Database. The survival outcomes in patients who underwent concurrent chemoradiotherapy (CCRT) and sequential chemotherapy and radiotherapy (SCRT) with either a short (SCRT1) or long (SCRT2) interval between treatments were estimated using Kaplan–Meier, Cox regression, and propensity score matching (PSM); (3) Results: Multivariate analyses of OS showed that SCRT2 (hazard ratio [HR] 0.64, <i>p</i> = 0.017) was associated with improved overall survival (OS). After PSM, the median OS periods were 64 and 75 months in the SCRT1 and SCRT2 groups, respectively, which differed significantly from that of 58 months in the CCRT group (<i>p</i> = 0.003). In elderly patients, SCRT2 significantly improved survival relative to CCRT before PSM (<i>p</i> = 0.024) and after PSM (<i>p</i> = 0.002); (4) Conclusions: A longer interval between initiation of adjuvant chemotherapy and postoperative radiotherapy (PORT; SCRT2) improved OS relative to CCRT; the benefits were greater in elderly patients (age >60 years).https://www.mdpi.com/2072-6694/13/10/2494postoperative radiotherapypostoperative chemotherapyNSCLCpN2IMRT |
| spellingShingle | Shih-Min Lin Hsiu-Ying Ku Che-Yu Hsu Chih-Liang Wang Gee-Chen Chang Cheng-Shyong Chang Tsang-Wu Liu Long-Term Survival Effect of the Interval between Postoperative Chemotherapy and Radiotherapy in Patients with Completely Resected Pathological N2 Non-Small-Cell Lung Cancer Cancers postoperative radiotherapy postoperative chemotherapy NSCLC pN2 IMRT |
| title | Long-Term Survival Effect of the Interval between Postoperative Chemotherapy and Radiotherapy in Patients with Completely Resected Pathological N2 Non-Small-Cell Lung Cancer |
| title_full | Long-Term Survival Effect of the Interval between Postoperative Chemotherapy and Radiotherapy in Patients with Completely Resected Pathological N2 Non-Small-Cell Lung Cancer |
| title_fullStr | Long-Term Survival Effect of the Interval between Postoperative Chemotherapy and Radiotherapy in Patients with Completely Resected Pathological N2 Non-Small-Cell Lung Cancer |
| title_full_unstemmed | Long-Term Survival Effect of the Interval between Postoperative Chemotherapy and Radiotherapy in Patients with Completely Resected Pathological N2 Non-Small-Cell Lung Cancer |
| title_short | Long-Term Survival Effect of the Interval between Postoperative Chemotherapy and Radiotherapy in Patients with Completely Resected Pathological N2 Non-Small-Cell Lung Cancer |
| title_sort | long term survival effect of the interval between postoperative chemotherapy and radiotherapy in patients with completely resected pathological n2 non small cell lung cancer |
| topic | postoperative radiotherapy postoperative chemotherapy NSCLC pN2 IMRT |
| url | https://www.mdpi.com/2072-6694/13/10/2494 |
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