The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients
ABSTRACT Introduction: Homocysteine (Hcy) is one of the metabolites of methionine (Met), an essential diet-derived amino acid. There is a close relationship between high plasma Hcy levels and declining renal function. Plasma and urinary Hcy level has been the target of studies as a biomarker that f...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Patologia Clínica
2018-06-01
|
| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000300170&tlng=en |
| _version_ | 1798021591530995712 |
|---|---|
| author | Bruna M. Martella Glaucia Raquel L. Veiga Beatriz C. A. Alves Ligia A. Azzalis Virginia B. C. Junqueira Flavia S. Gehrkei Fernando Luiz A. Fonseca Marcelo R. Bacci |
| author_facet | Bruna M. Martella Glaucia Raquel L. Veiga Beatriz C. A. Alves Ligia A. Azzalis Virginia B. C. Junqueira Flavia S. Gehrkei Fernando Luiz A. Fonseca Marcelo R. Bacci |
| author_sort | Bruna M. Martella |
| collection | DOAJ |
| description | ABSTRACT Introduction: Homocysteine (Hcy) is one of the metabolites of methionine (Met), an essential diet-derived amino acid. There is a close relationship between high plasma Hcy levels and declining renal function. Plasma and urinary Hcy level has been the target of studies as a biomarker that forecasts poor outcome in renal patients and in hemodialysis patients. This review evaluates the main studies that sought to correlate Hcy and poor prognosis in renal disease as well as the treatments proposed for the reduction of plasma Hcy levels in these patients. Conclusion: Hcy could be an important biomarker of renal disease progression mainly in hemodialysis patients. We emphasize the importance of normalizing plasma levels of this amino acid to ensure a better prognosis in kidney disease. |
| first_indexed | 2024-04-11T17:16:04Z |
| format | Article |
| id | doaj.art-a1e47a4e9d6b43c7883f5b6af7d1c125 |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-04-11T17:16:04Z |
| publishDate | 2018-06-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-a1e47a4e9d6b43c7883f5b6af7d1c1252022-12-22T04:12:39ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742018-06-0154317017610.5935/1676-2444.20180030The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patientsBruna M. MartellaGlaucia Raquel L. VeigaBeatriz C. A. AlvesLigia A. AzzalisVirginia B. C. JunqueiraFlavia S. GehrkeiFernando Luiz A. FonsecaMarcelo R. BacciABSTRACT Introduction: Homocysteine (Hcy) is one of the metabolites of methionine (Met), an essential diet-derived amino acid. There is a close relationship between high plasma Hcy levels and declining renal function. Plasma and urinary Hcy level has been the target of studies as a biomarker that forecasts poor outcome in renal patients and in hemodialysis patients. This review evaluates the main studies that sought to correlate Hcy and poor prognosis in renal disease as well as the treatments proposed for the reduction of plasma Hcy levels in these patients. Conclusion: Hcy could be an important biomarker of renal disease progression mainly in hemodialysis patients. We emphasize the importance of normalizing plasma levels of this amino acid to ensure a better prognosis in kidney disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000300170&tlng=enhomocysteinemetabolismchronic kidney failure |
| spellingShingle | Bruna M. Martella Glaucia Raquel L. Veiga Beatriz C. A. Alves Ligia A. Azzalis Virginia B. C. Junqueira Flavia S. Gehrkei Fernando Luiz A. Fonseca Marcelo R. Bacci The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients Jornal Brasileiro de Patologia e Medicina Laboratorial homocysteine metabolism chronic kidney failure |
| title | The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients |
| title_full | The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients |
| title_fullStr | The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients |
| title_full_unstemmed | The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients |
| title_short | The importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients |
| title_sort | importance of homocysteine levels in the prognosis of patients with chronic renal disease and in hemodialysis patients |
| topic | homocysteine metabolism chronic kidney failure |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000300170&tlng=en |
| work_keys_str_mv | AT brunammartella theimportanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT glauciaraquellveiga theimportanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT beatrizcaalves theimportanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT ligiaaazzalis theimportanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT virginiabcjunqueira theimportanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT flaviasgehrkei theimportanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT fernandoluizafonseca theimportanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT marcelorbacci theimportanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT brunammartella importanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT glauciaraquellveiga importanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT beatrizcaalves importanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT ligiaaazzalis importanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT virginiabcjunqueira importanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT flaviasgehrkei importanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT fernandoluizafonseca importanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients AT marcelorbacci importanceofhomocysteinelevelsintheprognosisofpatientswithchronicrenaldiseaseandinhemodialysispatients |