Natural Killer Cells in Post-Transplant Lymphoproliferative Disorders
Post-transplant lymphoproliferative disorders (PTLDs) are life-threatening complications arising after solid organ or hematopoietic stem cell transplantations. Although the majority of these lymphoproliferations are of B cell origin, and are frequently associated with primary Epstein–Barr virus (EBV...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/8/1836 |
| _version_ | 1797538004796964864 |
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| author | Cecilia Nakid-Cordero Marine Baron Amélie Guihot Vincent Vieillard |
| author_facet | Cecilia Nakid-Cordero Marine Baron Amélie Guihot Vincent Vieillard |
| author_sort | Cecilia Nakid-Cordero |
| collection | DOAJ |
| description | Post-transplant lymphoproliferative disorders (PTLDs) are life-threatening complications arising after solid organ or hematopoietic stem cell transplantations. Although the majority of these lymphoproliferations are of B cell origin, and are frequently associated with primary Epstein–Barr virus (EBV) infection or reactivation in the post-transplant period, rare cases of T cell and natural killer (NK) cell-originated PTLDs have also been described. A general assumption is that PTLDs result from the impairment of anti-viral and anti-tumoral immunosurveillance due to the long-term use of immunosuppressants in transplant recipients. T cell impairment is known to play a critical role in the immune-pathogenesis of post-transplant EBV-linked complications, while the role of NK cells has been less investigated, and is probably different between EBV-positive and EBV-negative PTLDs. As a part of the innate immune response, NK cells are critical for protecting hosts during the early response to virus-induced tumors. The complexity of their function is modulated by a myriad of activating and inhibitory receptors expressed on cell surfaces. This review outlines our current understanding of NK cells in the pathogenesis of PTLD, and discusses their potential implications for current PTLD therapies and novel NK cell-based therapies for the containment of these disorders. |
| first_indexed | 2024-03-10T12:24:18Z |
| format | Article |
| id | doaj.art-a1e4a3e492ae4ebb894a15c86ed302ac |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T12:24:18Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a1e4a3e492ae4ebb894a15c86ed302ac2023-11-21T15:12:55ZengMDPI AGCancers2072-66942021-04-01138183610.3390/cancers13081836Natural Killer Cells in Post-Transplant Lymphoproliferative DisordersCecilia Nakid-Cordero0Marine Baron1Amélie Guihot2Vincent Vieillard3Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), INSERM U1135, CNRS ERL8285, Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013 Paris, FranceCentre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), INSERM U1135, CNRS ERL8285, Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013 Paris, FranceCentre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), INSERM U1135, CNRS ERL8285, Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013 Paris, FranceCentre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), INSERM U1135, CNRS ERL8285, Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013 Paris, FrancePost-transplant lymphoproliferative disorders (PTLDs) are life-threatening complications arising after solid organ or hematopoietic stem cell transplantations. Although the majority of these lymphoproliferations are of B cell origin, and are frequently associated with primary Epstein–Barr virus (EBV) infection or reactivation in the post-transplant period, rare cases of T cell and natural killer (NK) cell-originated PTLDs have also been described. A general assumption is that PTLDs result from the impairment of anti-viral and anti-tumoral immunosurveillance due to the long-term use of immunosuppressants in transplant recipients. T cell impairment is known to play a critical role in the immune-pathogenesis of post-transplant EBV-linked complications, while the role of NK cells has been less investigated, and is probably different between EBV-positive and EBV-negative PTLDs. As a part of the innate immune response, NK cells are critical for protecting hosts during the early response to virus-induced tumors. The complexity of their function is modulated by a myriad of activating and inhibitory receptors expressed on cell surfaces. This review outlines our current understanding of NK cells in the pathogenesis of PTLD, and discusses their potential implications for current PTLD therapies and novel NK cell-based therapies for the containment of these disorders.https://www.mdpi.com/2072-6694/13/8/1836natural killer cellspost-transplant lymphoproliferative disordersEpstein–Barr virus |
| spellingShingle | Cecilia Nakid-Cordero Marine Baron Amélie Guihot Vincent Vieillard Natural Killer Cells in Post-Transplant Lymphoproliferative Disorders Cancers natural killer cells post-transplant lymphoproliferative disorders Epstein–Barr virus |
| title | Natural Killer Cells in Post-Transplant Lymphoproliferative Disorders |
| title_full | Natural Killer Cells in Post-Transplant Lymphoproliferative Disorders |
| title_fullStr | Natural Killer Cells in Post-Transplant Lymphoproliferative Disorders |
| title_full_unstemmed | Natural Killer Cells in Post-Transplant Lymphoproliferative Disorders |
| title_short | Natural Killer Cells in Post-Transplant Lymphoproliferative Disorders |
| title_sort | natural killer cells in post transplant lymphoproliferative disorders |
| topic | natural killer cells post-transplant lymphoproliferative disorders Epstein–Barr virus |
| url | https://www.mdpi.com/2072-6694/13/8/1836 |
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