Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, but the pathogenesis is not completely understood. The application of metabolomics could help in discovering new metabolic pathways involved in the development of the disease. Methods and Results We measured 112 baseline fast...
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| Format: | Article |
| Language: | English |
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Wiley
2020-11-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.120.016737 |
| _version_ | 1818307424615923712 |
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| author | Einar Smith Celine Fernandez Olle Melander Filip Ottosson |
| author_facet | Einar Smith Celine Fernandez Olle Melander Filip Ottosson |
| author_sort | Einar Smith |
| collection | DOAJ |
| description | Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, but the pathogenesis is not completely understood. The application of metabolomics could help in discovering new metabolic pathways involved in the development of the disease. Methods and Results We measured 112 baseline fasting metabolites of 3770 participants in the Malmö Diet and Cancer Study; these participants were free of prevalent AF. Incident cases of AF were ascertained through previously validated registers. The associations between baseline levels of metabolites and incident AF were investigated using Cox proportional hazard models. During 23.1 years of follow‐up, 650 cases of AF were identified (incidence rate: 8.6 per 1000 person‐years). In Cox regression models adjusted for AF risk factors, 7 medium‐ and long‐chain acylcarnitines were associated with higher risk of incident AF (hazard ratio [HR] ranging from 1.09; 95% CI, 1.00–1.18 to 1.14, 95% CI, 1.05–1.24 per 1 SD increment of acylcarnitines). Furthermore, caffeine and acisoga were also associated with an increased risk (HR, 1.17; 95% CI, 1.06–1.28 and 1.08; 95% CI, 1.00–1.18, respectively), while beta carotene was associated with a lower risk (HR, 0.90; 95% CI, 0.82–0.99). Conclusions For the first time, we show associations between altered acylcarnitine metabolism and incident AF independent of traditional AF risk factors in a general population. These findings highlight metabolic alterations that precede AF diagnosis by many years and could provide insight into the pathogenesis of AF. Future studies are needed to replicate our finding in an external cohort as well as to test whether the relationship between acylcarnitines and AF is causal. |
| first_indexed | 2024-12-13T06:58:10Z |
| format | Article |
| id | doaj.art-a1e4bfc27cfa4cfcbe148c658006305d |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T06:58:10Z |
| publishDate | 2020-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-a1e4bfc27cfa4cfcbe148c658006305d2022-12-21T23:56:00ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-11-0192110.1161/JAHA.120.016737Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial FibrillationEinar Smith0Celine Fernandez1Olle Melander2Filip Ottosson3Department of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenBackground Atrial fibrillation (AF) is the most common cardiac arrhythmia, but the pathogenesis is not completely understood. The application of metabolomics could help in discovering new metabolic pathways involved in the development of the disease. Methods and Results We measured 112 baseline fasting metabolites of 3770 participants in the Malmö Diet and Cancer Study; these participants were free of prevalent AF. Incident cases of AF were ascertained through previously validated registers. The associations between baseline levels of metabolites and incident AF were investigated using Cox proportional hazard models. During 23.1 years of follow‐up, 650 cases of AF were identified (incidence rate: 8.6 per 1000 person‐years). In Cox regression models adjusted for AF risk factors, 7 medium‐ and long‐chain acylcarnitines were associated with higher risk of incident AF (hazard ratio [HR] ranging from 1.09; 95% CI, 1.00–1.18 to 1.14, 95% CI, 1.05–1.24 per 1 SD increment of acylcarnitines). Furthermore, caffeine and acisoga were also associated with an increased risk (HR, 1.17; 95% CI, 1.06–1.28 and 1.08; 95% CI, 1.00–1.18, respectively), while beta carotene was associated with a lower risk (HR, 0.90; 95% CI, 0.82–0.99). Conclusions For the first time, we show associations between altered acylcarnitine metabolism and incident AF independent of traditional AF risk factors in a general population. These findings highlight metabolic alterations that precede AF diagnosis by many years and could provide insight into the pathogenesis of AF. Future studies are needed to replicate our finding in an external cohort as well as to test whether the relationship between acylcarnitines and AF is causal.https://www.ahajournals.org/doi/10.1161/JAHA.120.016737acylcarnitinesatrial fibrillationmetabolomics |
| spellingShingle | Einar Smith Celine Fernandez Olle Melander Filip Ottosson Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease acylcarnitines atrial fibrillation metabolomics |
| title | Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation |
| title_full | Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation |
| title_fullStr | Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation |
| title_full_unstemmed | Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation |
| title_short | Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation |
| title_sort | altered acylcarnitine metabolism is associated with an increased risk of atrial fibrillation |
| topic | acylcarnitines atrial fibrillation metabolomics |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.120.016737 |
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