Toxoplasma gondii seropositivity and serointensity and cognitive function in adults.
Infecting approximately one-third of the world's human population, Toxoplasma gondii has been associated with cognitive function. Here, we sought to further characterize the association between Toxoplasma gondii and cognitive function in a community sample of adults aged approximately 40 to70 y...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-10-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0008733 |
| _version_ | 1818726321074733056 |
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| author | Shawn D Gale Lance D Erickson Evan L Thacker Elizabeth L Mitchell Bruce L Brown Dawson W Hedges |
| author_facet | Shawn D Gale Lance D Erickson Evan L Thacker Elizabeth L Mitchell Bruce L Brown Dawson W Hedges |
| author_sort | Shawn D Gale |
| collection | DOAJ |
| description | Infecting approximately one-third of the world's human population, Toxoplasma gondii has been associated with cognitive function. Here, we sought to further characterize the association between Toxoplasma gondii and cognitive function in a community sample of adults aged approximately 40 to70 years. Using adjusted linear regression models, we found associations of Toxoplasma gondii seropositivity with worse reasoning (b = -.192, p < .05) and matrix pattern completion (b = -.681, p < .01), of higher anti-Toxoplasma gondii p22 antibody levels with worse reasoning (b = -.078, p < .01) and slower Trails (numeric) performance (b = 5.962, p < .05), of higher anti-Toxoplasma gondii sag1 levels with worse reasoning (b = -.081, p < .05) and worse matrix pattern completion (b = -.217, p < .05), and of higher mean of the anti-Toxoplasma gondii p22 and sag1 levels with worse reasoning (b = -.112, p < .05), slower Trails (numeric) performance (b = 9.195, p < .05), and worse matrix pattern completion (b = -.245, p < .05). Neither age nor educational attainment moderated associations between the measures of Toxoplasma gondii seropositivity or serointensity. Sex, however, moderated the association between the sag1 titer and digit-symbol substitution and the association between the mean of the p22 and sag1 levels and digit-symbol substitution, and income moderated the association between Toxoplasma gondii seropositivity and numeric memory and the association between the p22 level and symbol-digit substitution. Based on the available neuropsychological tasks in this study, Toxoplasma gondii seropositivity and serointensity were associated with some aspects of poorer executive function in adults. |
| first_indexed | 2024-12-17T21:56:20Z |
| format | Article |
| id | doaj.art-a1e54e78d4c447949f207bb3038f2b6c |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-17T21:56:20Z |
| publishDate | 2020-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-a1e54e78d4c447949f207bb3038f2b6c2022-12-21T21:31:07ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352020-10-011410e000873310.1371/journal.pntd.0008733Toxoplasma gondii seropositivity and serointensity and cognitive function in adults.Shawn D GaleLance D EricksonEvan L ThackerElizabeth L MitchellBruce L BrownDawson W HedgesInfecting approximately one-third of the world's human population, Toxoplasma gondii has been associated with cognitive function. Here, we sought to further characterize the association between Toxoplasma gondii and cognitive function in a community sample of adults aged approximately 40 to70 years. Using adjusted linear regression models, we found associations of Toxoplasma gondii seropositivity with worse reasoning (b = -.192, p < .05) and matrix pattern completion (b = -.681, p < .01), of higher anti-Toxoplasma gondii p22 antibody levels with worse reasoning (b = -.078, p < .01) and slower Trails (numeric) performance (b = 5.962, p < .05), of higher anti-Toxoplasma gondii sag1 levels with worse reasoning (b = -.081, p < .05) and worse matrix pattern completion (b = -.217, p < .05), and of higher mean of the anti-Toxoplasma gondii p22 and sag1 levels with worse reasoning (b = -.112, p < .05), slower Trails (numeric) performance (b = 9.195, p < .05), and worse matrix pattern completion (b = -.245, p < .05). Neither age nor educational attainment moderated associations between the measures of Toxoplasma gondii seropositivity or serointensity. Sex, however, moderated the association between the sag1 titer and digit-symbol substitution and the association between the mean of the p22 and sag1 levels and digit-symbol substitution, and income moderated the association between Toxoplasma gondii seropositivity and numeric memory and the association between the p22 level and symbol-digit substitution. Based on the available neuropsychological tasks in this study, Toxoplasma gondii seropositivity and serointensity were associated with some aspects of poorer executive function in adults.https://doi.org/10.1371/journal.pntd.0008733 |
| spellingShingle | Shawn D Gale Lance D Erickson Evan L Thacker Elizabeth L Mitchell Bruce L Brown Dawson W Hedges Toxoplasma gondii seropositivity and serointensity and cognitive function in adults. PLoS Neglected Tropical Diseases |
| title | Toxoplasma gondii seropositivity and serointensity and cognitive function in adults. |
| title_full | Toxoplasma gondii seropositivity and serointensity and cognitive function in adults. |
| title_fullStr | Toxoplasma gondii seropositivity and serointensity and cognitive function in adults. |
| title_full_unstemmed | Toxoplasma gondii seropositivity and serointensity and cognitive function in adults. |
| title_short | Toxoplasma gondii seropositivity and serointensity and cognitive function in adults. |
| title_sort | toxoplasma gondii seropositivity and serointensity and cognitive function in adults |
| url | https://doi.org/10.1371/journal.pntd.0008733 |
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