Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization

Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization

IntroductionResurgence of pertussis, caused by Bordetella pertussis, necessitates novel vaccines and vaccination strategies to combat this disease. Alum-adjuvanted acellular pertussis vaccines (aPV) delivered intramuscularly reduce bacterial numbers in the lungs of immunized animals and humans, but...

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Bibliographic Details
Main Authors: Kacy S. Yount, Jesse M. Hall, Kyle Caution, Mohamed M. Shamseldin, Myra Guo, Keirsten Marion, Audra R. Fullen, Yimin Huang, Jennifer A. Maynard, Sally A. Quataert, Rajendar Deora, Purnima Dubey
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
B. pertussis
mucosal immunity
tissue-resident memory T cells
BcfA
pertussis vaccines
adjuvants
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1181876/full

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