Mapping histoplasmosis in South East Asia – implications for diagnosis in AIDS
ABSTRACTHistoplasmosis caused by the fungus Histoplasma capsulatum is often lethal in patients with AIDS. Urine antigen testing is highly sensitive and much quicker for diagnosis than culture. Histoplasmosis has a patchy and incompletely appreciated distribution around the world especially in South...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1644539 |
| _version_ | 1797385780365099008 |
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| author | Jacob Baker Findra Setianingrum Retno Wahyuningsih David W. Denning |
| author_facet | Jacob Baker Findra Setianingrum Retno Wahyuningsih David W. Denning |
| author_sort | Jacob Baker |
| collection | DOAJ |
| description | ABSTRACTHistoplasmosis caused by the fungus Histoplasma capsulatum is often lethal in patients with AIDS. Urine antigen testing is highly sensitive and much quicker for diagnosis than culture. Histoplasmosis has a patchy and incompletely appreciated distribution around the world especially in South East Asia. We conducted a systematic literature review of cases of all disease forms of histoplasmosis in SE Asia, not including the Indian sub-continent. We also reviewed all histoplasmin skin test mapping studies to determine localities of exposure. We found a total of 407 cases contracted or likely to have been contracted in SE Asia. Numbers of cases by country varied: Thailand (233), Malaysia (76), Indonesia (48) and Singapore (21), with few or no cases reported in other countries. Most cases (255 (63%)) were disseminated histoplasmosis and 177 (43%) cases were HIV associated. Areas of high histoplasmin skin test sensitivity prevalence were found in Myanmar, the Philippines, Indonesia, Thailand and Vietnam - 86.4%, 26.0%, 63.6%, 36.0% and 33.7%, respectively. We have drawn maps of these data. Further study is required to ascertain the extent of histoplasmosis within SE Asia. Diagnostic capability for patients with HIV infection is urgently required in SE Asia, to reduce mortality and mis-diagnosis as tuberculosis. |
| first_indexed | 2024-03-08T21:59:12Z |
| format | Article |
| id | doaj.art-a1e800c97ced4b71adfb785d097698ef |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-08T21:59:12Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-a1e800c97ced4b71adfb785d097698ef2023-12-19T16:09:57ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811139114510.1080/22221751.2019.1644539Mapping histoplasmosis in South East Asia – implications for diagnosis in AIDSJacob Baker0Findra Setianingrum1Retno Wahyuningsih2David W. Denning3The University of Manchester and the Manchester Academic Health Service Centre, Manchester, UKThe University of Manchester and the Manchester Academic Health Service Centre, Manchester, UKFaculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaThe University of Manchester and the Manchester Academic Health Service Centre, Manchester, UKABSTRACTHistoplasmosis caused by the fungus Histoplasma capsulatum is often lethal in patients with AIDS. Urine antigen testing is highly sensitive and much quicker for diagnosis than culture. Histoplasmosis has a patchy and incompletely appreciated distribution around the world especially in South East Asia. We conducted a systematic literature review of cases of all disease forms of histoplasmosis in SE Asia, not including the Indian sub-continent. We also reviewed all histoplasmin skin test mapping studies to determine localities of exposure. We found a total of 407 cases contracted or likely to have been contracted in SE Asia. Numbers of cases by country varied: Thailand (233), Malaysia (76), Indonesia (48) and Singapore (21), with few or no cases reported in other countries. Most cases (255 (63%)) were disseminated histoplasmosis and 177 (43%) cases were HIV associated. Areas of high histoplasmin skin test sensitivity prevalence were found in Myanmar, the Philippines, Indonesia, Thailand and Vietnam - 86.4%, 26.0%, 63.6%, 36.0% and 33.7%, respectively. We have drawn maps of these data. Further study is required to ascertain the extent of histoplasmosis within SE Asia. Diagnostic capability for patients with HIV infection is urgently required in SE Asia, to reduce mortality and mis-diagnosis as tuberculosis.https://www.tandfonline.com/doi/10.1080/22221751.2019.1644539HistoplasmaAIDSadrenaldisseminatedskin testing |
| spellingShingle | Jacob Baker Findra Setianingrum Retno Wahyuningsih David W. Denning Mapping histoplasmosis in South East Asia – implications for diagnosis in AIDS Emerging Microbes and Infections Histoplasma AIDS adrenal disseminated skin testing |
| title | Mapping histoplasmosis in South East Asia – implications for diagnosis in AIDS |
| title_full | Mapping histoplasmosis in South East Asia – implications for diagnosis in AIDS |
| title_fullStr | Mapping histoplasmosis in South East Asia – implications for diagnosis in AIDS |
| title_full_unstemmed | Mapping histoplasmosis in South East Asia – implications for diagnosis in AIDS |
| title_short | Mapping histoplasmosis in South East Asia – implications for diagnosis in AIDS |
| title_sort | mapping histoplasmosis in south east asia implications for diagnosis in aids |
| topic | Histoplasma AIDS adrenal disseminated skin testing |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1644539 |
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