Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1
PU.1 is a master TF of hematopoietic lineage differentiation. Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the mechanisms governing the pioneering and redistribution capabiliti...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13960-2 |
| _version_ | 1830206771278381056 |
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| author | Julia Minderjahn Andreas Schmidt Andreas Fuchs Rudolf Schill Johanna Raithel Magda Babina Christian Schmidl Claudia Gebhard Sandra Schmidhofer Karina Mendes Anna Ratermann Dagmar Glatz Margit Nützel Matthias Edinger Petra Hoffmann Rainer Spang Gernot Längst Axel Imhof Michael Rehli |
| author_facet | Julia Minderjahn Andreas Schmidt Andreas Fuchs Rudolf Schill Johanna Raithel Magda Babina Christian Schmidl Claudia Gebhard Sandra Schmidhofer Karina Mendes Anna Ratermann Dagmar Glatz Margit Nützel Matthias Edinger Petra Hoffmann Rainer Spang Gernot Längst Axel Imhof Michael Rehli |
| author_sort | Julia Minderjahn |
| collection | DOAJ |
| description | PU.1 is a master TF of hematopoietic lineage differentiation. Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1. |
| first_indexed | 2024-12-18T04:19:34Z |
| format | Article |
| id | doaj.art-a1e8607ec20a48c6b05e13fafbd8d67e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:19:34Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a1e8607ec20a48c6b05e13fafbd8d67e2022-12-21T21:21:16ZengNature PortfolioNature Communications2041-17232020-01-0111111610.1038/s41467-019-13960-2Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1Julia Minderjahn0Andreas Schmidt1Andreas Fuchs2Rudolf Schill3Johanna Raithel4Magda Babina5Christian Schmidl6Claudia Gebhard7Sandra Schmidhofer8Karina Mendes9Anna Ratermann10Dagmar Glatz11Margit Nützel12Matthias Edinger13Petra Hoffmann14Rainer Spang15Gernot Längst16Axel Imhof17Michael Rehli18Department of Internal Medicine III, University Hospital RegensburgBiomedical Center, Protein Analysis Unit, Faculty of Medicine, Ludwig-Maximilians-Universität MünchenBiochemistry Centre Regensburg (BCR), University of RegensburgStatistical Bioinformatics Department, Institute of Functional Genomics, University of RegensburgDepartment of Internal Medicine III, University Hospital RegensburgDepartment of Dermatology and Allergy, Charité Universitätsmedizin BerlinRegensburg Center for Interventional Immunology (RCI), University Regensburg and University Medical Center RegensburgDepartment of Internal Medicine III, University Hospital RegensburgDepartment of Internal Medicine III, University Hospital RegensburgDepartment of Internal Medicine III, University Hospital RegensburgDepartment of Internal Medicine III, University Hospital RegensburgDepartment of Internal Medicine III, University Hospital RegensburgDepartment of Internal Medicine III, University Hospital RegensburgDepartment of Internal Medicine III, University Hospital RegensburgDepartment of Internal Medicine III, University Hospital RegensburgStatistical Bioinformatics Department, Institute of Functional Genomics, University of RegensburgBiochemistry Centre Regensburg (BCR), University of RegensburgBiomedical Center, Protein Analysis Unit, Faculty of Medicine, Ludwig-Maximilians-Universität MünchenDepartment of Internal Medicine III, University Hospital RegensburgPU.1 is a master TF of hematopoietic lineage differentiation. Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1.https://doi.org/10.1038/s41467-019-13960-2 |
| spellingShingle | Julia Minderjahn Andreas Schmidt Andreas Fuchs Rudolf Schill Johanna Raithel Magda Babina Christian Schmidl Claudia Gebhard Sandra Schmidhofer Karina Mendes Anna Ratermann Dagmar Glatz Margit Nützel Matthias Edinger Petra Hoffmann Rainer Spang Gernot Längst Axel Imhof Michael Rehli Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1 Nature Communications |
| title | Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1 |
| title_full | Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1 |
| title_fullStr | Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1 |
| title_full_unstemmed | Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1 |
| title_short | Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1 |
| title_sort | mechanisms governing the pioneering and redistribution capabilities of the non classical pioneer pu 1 |
| url | https://doi.org/10.1038/s41467-019-13960-2 |
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