The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

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Summary: AXL is activated by its ligand GAS6 and is expressed in triple-negative breast cancer cells. In the current study, we report AXL expression in HER2-positive (HER2+) breast cancers where it correlates with poor patient survival. Using murine models of HER2+ breast cancer, Axl, but not its li...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Marie-Anne Goyette, Stéphanie Duhamel, Léo Aubert, Ariane Pelletier, Paul Savage, Marie-Pier Thibault, Radia Marie Johnson, Peter Carmeliet, Mark Basik, Louis Gaboury, William J. Muller, Morag Park, Philippe P. Roux, Jean-Philippe Gratton, Jean-François Côté
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Elsevier 2018-05-01
Цуврал:Cell Reports
Онлайн хандалт:http://www.sciencedirect.com/science/article/pii/S2211124718305485

Интернэт

http://www.sciencedirect.com/science/article/pii/S2211124718305485

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