Cancer as a metabolic disease
<p>Abstract</p> <p>Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-01-01
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| Series: | Nutrition & Metabolism |
| Online Access: | http://www.nutritionandmetabolism.com/content/7/1/7 |
| _version_ | 1818666862880227328 |
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| author | Shelton Laura M Seyfried Thomas N |
| author_facet | Shelton Laura M Seyfried Thomas N |
| author_sort | Shelton Laura M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.</p> |
| first_indexed | 2024-12-17T06:11:17Z |
| format | Article |
| id | doaj.art-a1edfdb6df9d477ea809fd223983aa3c |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-12-17T06:11:17Z |
| publishDate | 2010-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-a1edfdb6df9d477ea809fd223983aa3c2022-12-21T22:00:37ZengBMCNutrition & Metabolism1743-70752010-01-0171710.1186/1743-7075-7-7Cancer as a metabolic diseaseShelton Laura MSeyfried Thomas N<p>Abstract</p> <p>Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.</p>http://www.nutritionandmetabolism.com/content/7/1/7 |
| spellingShingle | Shelton Laura M Seyfried Thomas N Cancer as a metabolic disease Nutrition & Metabolism |
| title | Cancer as a metabolic disease |
| title_full | Cancer as a metabolic disease |
| title_fullStr | Cancer as a metabolic disease |
| title_full_unstemmed | Cancer as a metabolic disease |
| title_short | Cancer as a metabolic disease |
| title_sort | cancer as a metabolic disease |
| url | http://www.nutritionandmetabolism.com/content/7/1/7 |
| work_keys_str_mv | AT sheltonlauram cancerasametabolicdisease AT seyfriedthomasn cancerasametabolicdisease |