The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT
Background: Abnormality of left ventricular (LV) diastolic function is frequently the earliest indicator of LV dysfunction in many diseases, including coronary artery disease (CAD), and hypertension. Electrocardiography (ECG)-gated technetium (Tc)-99 m tetrofosmin single-photon emission computed tom...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-09-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X15000728 |
| _version_ | 1819152636588326912 |
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| author | Mohamed H.M. Sayed A.O. Eltayeb Hussein R.S. Farghaly |
| author_facet | Mohamed H.M. Sayed A.O. Eltayeb Hussein R.S. Farghaly |
| author_sort | Mohamed H.M. Sayed |
| collection | DOAJ |
| description | Background: Abnormality of left ventricular (LV) diastolic function is frequently the earliest indicator of LV dysfunction in many diseases, including coronary artery disease (CAD), and hypertension. Electrocardiography (ECG)-gated technetium (Tc)-99 m tetrofosmin single-photon emission computed tomography (SPECT) has been reported to be a useful method for evaluation of LV function.
Objectives: The purpose of this study was to assess the impact of hypertension on diastolic left ventricular function using ECG-gated Tc-99m tetrofosmin SPECT.
Methods: Thirty consecutive patients with normal exercise myocardial perfusion and normal LV systolic function, were studied out of 233 patients underwent ECG-gated Tc-99m tetrofosmin SPECT at our institution between January 2012 and December 2013. Patients were divided into two groups according to the presence or absence of systemic hypertension (blood pressure ⩾140/90 mm Hg on ⩾3 measurements or treatment with antihypertensive medication). Parameters of diastolic LV function were assessed.
Results: Of the studied 30 patients, 19/30 (63%) had hypertension. There was no difference with respect to age, gender, LV end-diastolic volume (EDV), LV end-systolic volume (ESV), and LV ejection fraction values obtained by quantitative gated SPECT between patients with and without hypertension. The first-third mean filling rate (1/3 MFR), peak filling rate (PFR) of patients with hypertension (1.22 ± 0.38, 2.83 ± 1.10 EDV/s) were lower than those of patients without hypertension (1.54 ± 0.30, 2.90 ± 0.35 EDV/s), and the time to peak filling (TTPF) of patients with hypertension (199.42 ± 68.34 ms) was higher than TTPF of patients without hypertension (164.90 ± 36.39 ms).
Conclusions: Quantitative ECG-gated Tc-99m tetrofosmin SPECT reveals that hypertensive patients with preserved global LV systolic function may have significant changes in diastolic LV function. Gated myocardial perfusion SPECT reports are always lacking in these changes in diastolic function. We recommend inclusion of such changes in diastolic function in gated myocardial perfusion SPECT reports that can help in proper management of hypertensive patients. |
| first_indexed | 2024-12-22T14:52:27Z |
| format | Article |
| id | doaj.art-a1ee33eddc924b90a7462ec4c2e70ad9 |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-22T14:52:27Z |
| publishDate | 2015-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-a1ee33eddc924b90a7462ec4c2e70ad92022-12-21T18:22:18ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2015-09-0146359960310.1016/j.ejrnm.2015.04.003The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECTMohamed H.M. Sayed0A.O. Eltayeb1Hussein R.S. Farghaly2Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Cardiology, Almana General Hospital, Dammam, Saudi ArabiaDepartment of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University, Assiut, EgyptBackground: Abnormality of left ventricular (LV) diastolic function is frequently the earliest indicator of LV dysfunction in many diseases, including coronary artery disease (CAD), and hypertension. Electrocardiography (ECG)-gated technetium (Tc)-99 m tetrofosmin single-photon emission computed tomography (SPECT) has been reported to be a useful method for evaluation of LV function. Objectives: The purpose of this study was to assess the impact of hypertension on diastolic left ventricular function using ECG-gated Tc-99m tetrofosmin SPECT. Methods: Thirty consecutive patients with normal exercise myocardial perfusion and normal LV systolic function, were studied out of 233 patients underwent ECG-gated Tc-99m tetrofosmin SPECT at our institution between January 2012 and December 2013. Patients were divided into two groups according to the presence or absence of systemic hypertension (blood pressure ⩾140/90 mm Hg on ⩾3 measurements or treatment with antihypertensive medication). Parameters of diastolic LV function were assessed. Results: Of the studied 30 patients, 19/30 (63%) had hypertension. There was no difference with respect to age, gender, LV end-diastolic volume (EDV), LV end-systolic volume (ESV), and LV ejection fraction values obtained by quantitative gated SPECT between patients with and without hypertension. The first-third mean filling rate (1/3 MFR), peak filling rate (PFR) of patients with hypertension (1.22 ± 0.38, 2.83 ± 1.10 EDV/s) were lower than those of patients without hypertension (1.54 ± 0.30, 2.90 ± 0.35 EDV/s), and the time to peak filling (TTPF) of patients with hypertension (199.42 ± 68.34 ms) was higher than TTPF of patients without hypertension (164.90 ± 36.39 ms). Conclusions: Quantitative ECG-gated Tc-99m tetrofosmin SPECT reveals that hypertensive patients with preserved global LV systolic function may have significant changes in diastolic LV function. Gated myocardial perfusion SPECT reports are always lacking in these changes in diastolic function. We recommend inclusion of such changes in diastolic function in gated myocardial perfusion SPECT reports that can help in proper management of hypertensive patients.http://www.sciencedirect.com/science/article/pii/S0378603X15000728HypertensionLeft ventricular diastolic functionQuantitative ECG-gated SPECT |
| spellingShingle | Mohamed H.M. Sayed A.O. Eltayeb Hussein R.S. Farghaly The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT The Egyptian Journal of Radiology and Nuclear Medicine Hypertension Left ventricular diastolic function Quantitative ECG-gated SPECT |
| title | The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT |
| title_full | The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT |
| title_fullStr | The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT |
| title_full_unstemmed | The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT |
| title_short | The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT |
| title_sort | impact of hypertension on diastolic left ventricular function evaluated by quantitative ecg gated myocardial perfusion spect |
| topic | Hypertension Left ventricular diastolic function Quantitative ECG-gated SPECT |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X15000728 |
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