Short and long-term mortality in severe sepsis/septic Shock in a setting with low antibiotic resistance centers
Background: Sepsis, which is a common inflammatory response to severe infection, is one of the major causes of mortality in hospitalized patients. Sepsis, severe sepsis or sepsis syndrome, and eventually septic shock, may be seen in the development of infection. The aim of this study was to evaluate...
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| Format: | Article |
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Tabriz University of Medical Sciences
2020-12-01
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| Series: | مجله پزشکی دانشگاه علوم پزشکی تبریز |
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| Online Access: | https://mj.tbzmed.ac.ir/PDF/mj-42-547.pdf |
| _version_ | 1797962223027486720 |
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| author | Parviz Saleh Zeinolabedin Khodaie Negar Mohtadi |
| author_facet | Parviz Saleh Zeinolabedin Khodaie Negar Mohtadi |
| author_sort | Parviz Saleh |
| collection | DOAJ |
| description | Background: Sepsis, which is a common inflammatory response to severe infection, is one of the major causes of mortality in hospitalized patients. Sepsis, severe sepsis or sepsis syndrome, and eventually septic shock, may be seen in the development of infection. The aim of this study was to evaluate the short-term and long-term mortality in patients with severe sepsis and septic shock in centers with low antibiotic resistance. Methods: In this cross-sectional study, blood culture samples and peripheral blood samples were taken from all patients for para-clinical tests. The severity of severe sepsis and septic shock was assessed by the APACHE II and SOFA clinical criteria. Sepsis risk factors and primary causes of sepsis were recorded. Results: From 100 patients, 55% had severe sepsis and 45% had septic shock. SOFA24h and SOFA96h scores were significantly higher in patients with septic shock. The most common primary cause of sepsis was related to abdominal infections with a frequency of 42%. The frequency of confirmed positive blood culture was 53%. The most commonly isolated pathogen was E.coli with a frequency of 66%. Short-term mortality was 29% and long-term mortality was 28.2%. Conclusion: The main risk factors affecting the mortality of patients were age-related septic shock, cardiovascular disease; hypertension, immunosuppression, and SOFA score. |
| first_indexed | 2024-04-11T01:11:00Z |
| format | Article |
| id | doaj.art-a1ee847245b740c590a19c71efbbc86c |
| institution | Directory Open Access Journal |
| issn | 2783-2031 2783-204X |
| language | fas |
| last_indexed | 2024-04-11T01:11:00Z |
| publishDate | 2020-12-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | مجله پزشکی دانشگاه علوم پزشکی تبریز |
| spelling | doaj.art-a1ee847245b740c590a19c71efbbc86c2023-01-04T07:18:08ZfasTabriz University of Medical Sciencesمجله پزشکی دانشگاه علوم پزشکی تبریز2783-20312783-204X2020-12-0142554755510.34172/mj.2020.07826029Short and long-term mortality in severe sepsis/septic Shock in a setting with low antibiotic resistance centersParviz Saleh0Zeinolabedin Khodaie1Negar Mohtadi2Department of Infectious and Tropical Disease, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Infectious and Tropical Disease, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Infectious and Tropical Disease, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranBackground: Sepsis, which is a common inflammatory response to severe infection, is one of the major causes of mortality in hospitalized patients. Sepsis, severe sepsis or sepsis syndrome, and eventually septic shock, may be seen in the development of infection. The aim of this study was to evaluate the short-term and long-term mortality in patients with severe sepsis and septic shock in centers with low antibiotic resistance. Methods: In this cross-sectional study, blood culture samples and peripheral blood samples were taken from all patients for para-clinical tests. The severity of severe sepsis and septic shock was assessed by the APACHE II and SOFA clinical criteria. Sepsis risk factors and primary causes of sepsis were recorded. Results: From 100 patients, 55% had severe sepsis and 45% had septic shock. SOFA24h and SOFA96h scores were significantly higher in patients with septic shock. The most common primary cause of sepsis was related to abdominal infections with a frequency of 42%. The frequency of confirmed positive blood culture was 53%. The most commonly isolated pathogen was E.coli with a frequency of 66%. Short-term mortality was 29% and long-term mortality was 28.2%. Conclusion: The main risk factors affecting the mortality of patients were age-related septic shock, cardiovascular disease; hypertension, immunosuppression, and SOFA score.https://mj.tbzmed.ac.ir/PDF/mj-42-547.pdfmortalitysevere sepsisseptic shockantibiotic resistancerisk factor |
| spellingShingle | Parviz Saleh Zeinolabedin Khodaie Negar Mohtadi Short and long-term mortality in severe sepsis/septic Shock in a setting with low antibiotic resistance centers مجله پزشکی دانشگاه علوم پزشکی تبریز mortality severe sepsis septic shock antibiotic resistance risk factor |
| title | Short and long-term mortality in severe sepsis/septic Shock in a setting with low antibiotic resistance centers |
| title_full | Short and long-term mortality in severe sepsis/septic Shock in a setting with low antibiotic resistance centers |
| title_fullStr | Short and long-term mortality in severe sepsis/septic Shock in a setting with low antibiotic resistance centers |
| title_full_unstemmed | Short and long-term mortality in severe sepsis/septic Shock in a setting with low antibiotic resistance centers |
| title_short | Short and long-term mortality in severe sepsis/septic Shock in a setting with low antibiotic resistance centers |
| title_sort | short and long term mortality in severe sepsis septic shock in a setting with low antibiotic resistance centers |
| topic | mortality severe sepsis septic shock antibiotic resistance risk factor |
| url | https://mj.tbzmed.ac.ir/PDF/mj-42-547.pdf |
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