Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile Spasms
Objective:The study aimed to identify the signatures of brain networks using electroencephalogram (EEG) in patients with infantile spasms (IS).MethodsScalp EEGs of subjects with IS were prospectively collected in the first year of life (n = 8; age range 4–8 months; 3 males, 5 females). Ten minutes o...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.878099/full |
| _version_ | 1828040189713317888 |
|---|---|
| author | Yan Dong Ruijuan Xu Yaodong Zhang Yali Shi Kaixian Du Tianming Jia Jun Wang Fang Wang |
| author_facet | Yan Dong Ruijuan Xu Yaodong Zhang Yali Shi Kaixian Du Tianming Jia Jun Wang Fang Wang |
| author_sort | Yan Dong |
| collection | DOAJ |
| description | Objective:The study aimed to identify the signatures of brain networks using electroencephalogram (EEG) in patients with infantile spasms (IS).MethodsScalp EEGs of subjects with IS were prospectively collected in the first year of life (n = 8; age range 4–8 months; 3 males, 5 females). Ten minutes of ictal and interictal EEGs were clipped and filtered into different EEG frequency bands. The values of each pair of EEG channels were directly compared between ictal with interictal onsets and the sleep-wake phase to calculate IS brain network attributes: characteristic path length (CPL), node degree (ND), clustering coefficient (CC), and betweenness centrality (BC).ResultsCPL, ND, and CC of the fast waves decreased while BC increased. CPL and BC of the slow waves decreased, while ND and CC increased during the IS ictal onset (P < 0.05). CPL of the alpha decreased, and BC increased during the waking time (P < 0.05).ConclusionThe transmission capability of the fast waves, the local connectivity, and the defense capability of the slow waves during the IS ictal onset were enhanced. The alpha band played the most important role in both the global and local networks during the waking time. These may represent the brain network signatures of IS. |
| first_indexed | 2024-04-10T16:53:17Z |
| format | Article |
| id | doaj.art-a1efaccf7e9e45808abaa54c86ae4fbf |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T16:53:17Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-a1efaccf7e9e45808abaa54c86ae4fbf2023-02-07T11:18:46ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-05-011010.3389/fped.2022.878099878099Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile SpasmsYan Dong0Ruijuan Xu1Yaodong Zhang2Yali Shi3Kaixian Du4Tianming Jia5Jun Wang6Fang Wang7Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou, ChinaHenan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou, ChinaHenan Key Laboratory of Children's Genetics and Metabolic Diseases, Henan Neurodevelopment Engineering Research Center for Children, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou, ChinaHenan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou, ChinaHenan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou, ChinaDepartment of Children's Rehabilitation, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Medical Record Management, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaObjective:The study aimed to identify the signatures of brain networks using electroencephalogram (EEG) in patients with infantile spasms (IS).MethodsScalp EEGs of subjects with IS were prospectively collected in the first year of life (n = 8; age range 4–8 months; 3 males, 5 females). Ten minutes of ictal and interictal EEGs were clipped and filtered into different EEG frequency bands. The values of each pair of EEG channels were directly compared between ictal with interictal onsets and the sleep-wake phase to calculate IS brain network attributes: characteristic path length (CPL), node degree (ND), clustering coefficient (CC), and betweenness centrality (BC).ResultsCPL, ND, and CC of the fast waves decreased while BC increased. CPL and BC of the slow waves decreased, while ND and CC increased during the IS ictal onset (P < 0.05). CPL of the alpha decreased, and BC increased during the waking time (P < 0.05).ConclusionThe transmission capability of the fast waves, the local connectivity, and the defense capability of the slow waves during the IS ictal onset were enhanced. The alpha band played the most important role in both the global and local networks during the waking time. These may represent the brain network signatures of IS.https://www.frontiersin.org/articles/10.3389/fped.2022.878099/fullEEGs analysisinfantile spasmslocal networkglobal networkfunctional brain networks |
| spellingShingle | Yan Dong Ruijuan Xu Yaodong Zhang Yali Shi Kaixian Du Tianming Jia Jun Wang Fang Wang Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile Spasms Frontiers in Pediatrics EEGs analysis infantile spasms local network global network functional brain networks |
| title | Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile Spasms |
| title_full | Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile Spasms |
| title_fullStr | Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile Spasms |
| title_full_unstemmed | Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile Spasms |
| title_short | Different Frequency Bands in Various Regions of the Brain Play Different Roles in the Onset and Wake-Sleep Stages of Infantile Spasms |
| title_sort | different frequency bands in various regions of the brain play different roles in the onset and wake sleep stages of infantile spasms |
| topic | EEGs analysis infantile spasms local network global network functional brain networks |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.878099/full |
| work_keys_str_mv | AT yandong differentfrequencybandsinvariousregionsofthebrainplaydifferentrolesintheonsetandwakesleepstagesofinfantilespasms AT ruijuanxu differentfrequencybandsinvariousregionsofthebrainplaydifferentrolesintheonsetandwakesleepstagesofinfantilespasms AT yaodongzhang differentfrequencybandsinvariousregionsofthebrainplaydifferentrolesintheonsetandwakesleepstagesofinfantilespasms AT yalishi differentfrequencybandsinvariousregionsofthebrainplaydifferentrolesintheonsetandwakesleepstagesofinfantilespasms AT kaixiandu differentfrequencybandsinvariousregionsofthebrainplaydifferentrolesintheonsetandwakesleepstagesofinfantilespasms AT tianmingjia differentfrequencybandsinvariousregionsofthebrainplaydifferentrolesintheonsetandwakesleepstagesofinfantilespasms AT junwang differentfrequencybandsinvariousregionsofthebrainplaydifferentrolesintheonsetandwakesleepstagesofinfantilespasms AT fangwang differentfrequencybandsinvariousregionsofthebrainplaydifferentrolesintheonsetandwakesleepstagesofinfantilespasms |