IgE-associated IGHV genes from venom and peanut allergic individuals lack mutational evidence of antigen selection.

IgE-associated IGHV genes from venom and peanut allergic individuals lack mutational evidence of antigen selection.

Antigen selection of B cells within the germinal center reaction generally leads to the accumulation of replacement mutations in the complementarity-determining regions (CDRs) of immunoglobulin genes. Studies of mutations in IgE-associated VDJ gene sequences have cast doubt on the role of antigen se...

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Bibliographic Details
Main Authors: Yan Wang, Katherine J L Jackson, Janet Davies, Zhiliang Chen, Bruno A Gaeta, Janet Rimmer, William A Sewell, Andrew M Collins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089730&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089730&type=printable

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