Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury
Spinal cord injury (SCI) is a disastrous situation that affects many patients worldwide. A profound understanding of the pathology and etiology of SCI is of great importance in inspiring new therapeutic concepts and treatment. In recent years, exosomes, which are complex lipid membrane structures se...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Journal of Orthopaedic Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X21000759 |
| _version_ | 1818967545880772608 |
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| author | Dayu Pan Weixiao Liu Shibo Zhu Baoyou Fan Nanxi Yu Guangzhi Ning Shiqing Feng |
| author_facet | Dayu Pan Weixiao Liu Shibo Zhu Baoyou Fan Nanxi Yu Guangzhi Ning Shiqing Feng |
| author_sort | Dayu Pan |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is a disastrous situation that affects many patients worldwide. A profound understanding of the pathology and etiology of SCI is of great importance in inspiring new therapeutic concepts and treatment. In recent years, exosomes, which are complex lipid membrane structures secreted nearly by all kinds of plants and animal cells, can transport their valuable cargoes (e.g., proteins, lipids, RNAs) to the targeted cells and exert their communication and regulation functions, which open up a new field of treatment of SCI. Notably, the exosome's advantage is transporting the carried material to the target cells across the blood–brain barrier and exerting regulatory functions. Among the cargoes of exosomes, microRNAs, through the modulation of their mRNA targets, emerges with great potentiality in the pathological process, diagnosis and treatment of SCI. In this review, we discuss the role of miRNAs transported by different cell-derived exosomes in SCI that are poised to enhance SCI-specific therapeutic capabilities of exosomes. |
| first_indexed | 2024-12-20T13:50:30Z |
| format | Article |
| id | doaj.art-a1f0efeec9c24935bab0a5063232f309 |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-12-20T13:50:30Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-a1f0efeec9c24935bab0a5063232f3092022-12-21T19:38:33ZengElsevierJournal of Orthopaedic Translation2214-031X2021-11-01313340Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injuryDayu Pan0Weixiao Liu1Shibo Zhu2Baoyou Fan3Nanxi Yu4Guangzhi Ning5Shiqing Feng6Department of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin, 300052, PR China; Tianjin Neurological Institute, Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Heping District, Tianjin, 300052, PR ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin, 300052, PR China; Tianjin Neurological Institute, Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Heping District, Tianjin, 300052, PR ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin, 300052, PR China; Tianjin Neurological Institute, Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Heping District, Tianjin, 300052, PR ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin, 300052, PR China; Tianjin Neurological Institute, Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Heping District, Tianjin, 300052, PR ChinaDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin, 300052, PR China; Tianjin Neurological Institute, Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Heping District, Tianjin, 300052, PR China; Corresponding author. Department of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin, 300052, PR China.Department of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin, 300052, PR China; Tianjin Neurological Institute, Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Heping District, Tianjin, 300052, PR China; Corresponding author. Department of Orthopedic Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.Spinal cord injury (SCI) is a disastrous situation that affects many patients worldwide. A profound understanding of the pathology and etiology of SCI is of great importance in inspiring new therapeutic concepts and treatment. In recent years, exosomes, which are complex lipid membrane structures secreted nearly by all kinds of plants and animal cells, can transport their valuable cargoes (e.g., proteins, lipids, RNAs) to the targeted cells and exert their communication and regulation functions, which open up a new field of treatment of SCI. Notably, the exosome's advantage is transporting the carried material to the target cells across the blood–brain barrier and exerting regulatory functions. Among the cargoes of exosomes, microRNAs, through the modulation of their mRNA targets, emerges with great potentiality in the pathological process, diagnosis and treatment of SCI. In this review, we discuss the role of miRNAs transported by different cell-derived exosomes in SCI that are poised to enhance SCI-specific therapeutic capabilities of exosomes.http://www.sciencedirect.com/science/article/pii/S2214031X21000759Spinal cord injuryMicroRNAExosome |
| spellingShingle | Dayu Pan Weixiao Liu Shibo Zhu Baoyou Fan Nanxi Yu Guangzhi Ning Shiqing Feng Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury Journal of Orthopaedic Translation Spinal cord injury MicroRNA Exosome |
| title | Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury |
| title_full | Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury |
| title_fullStr | Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury |
| title_full_unstemmed | Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury |
| title_short | Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury |
| title_sort | potential of different cells derived exosomal microrna cargos for treating spinal cord injury |
| topic | Spinal cord injury MicroRNA Exosome |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X21000759 |
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