Predicting preeclampsia course based on endothelium-dependent dilation
<p> <b>R.Kh. Shavaeva, A.V. Murashko, V.M. Zuev, S.A. Timofeev, T.A. Dzhibladze</b> </p> <p> I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, <br> Russian Federation </p> <p> <b>Aim</b>: to determine...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LCC «Medicine-Inform»
2021-12-01
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| Series: | РМЖ. Мать и дитя |
| Online Access: | http://wchjournal.com/upload/iblock/299/299abdb63f8e285eaad2a4a2c8a30be2.pdf |
| Summary: | <p>
<b>R.Kh. Shavaeva, A.V. Murashko, V.M. Zuev, S.A. Timofeev, T.A. Dzhibladze</b>
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I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, <br>
Russian Federation
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<b>Aim</b>: to determine prognostic criteria of severe preeclampsia based on the assessment of endothelium-dependent (ED) flow-mediated dilation (FMD) of the brachial artery (BA).
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<b>Patients and Methods:</b> 97 pregnant women (>28 weeks of pregnancy) with moderate preeclampsia were enrolled. These women were retrospectively divided into two groups. Group 1 included 42 pregnant women (mean age 30.0±0.5 years) in whom the severity of preeclampsia increased after treatment. Group 2 included 55 pregnant women (mean age 31.0±0.7 years) whose severity of preeclampsia did not increase after treatment. Group 3 (control group) included 20 women with a healthy pregnancy. ED FMD of BA was assessed by vascular ultrasound using a reactive hyperemia test. In addition, BA diameter and peak systolic velocity (PSV) 15 sec and 1 min after cuff deflation were measured. These measurements were performed at enrollment and after one week (or in feeling worse).
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<b>Results</b>: healthy pregnancy was characterized by a gradual increase in BA diameter in response to cuff inflation (by 15.7% and 23.9% after 15 sec and 1 min, respectively, at baseline and by 17.8% and 21.3% after 15 sec and 1 min, respectively, after one week). In pregnant women with preeclampsia, baseline changes in BA diameter were less significant. Meanwhile, after one week, a reduction in BA diameter was reported in group 1, and close-to-normal BA diameter was reported in group 2. In group 3, BA PSV increased by 5.2% and 16% in 15 sec and 1 min, respectively, after cuff inflation. In pregnant women with preeclampsia, BA PSV, in contrast, was reduced (more significant after 1 min).
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<b>Conclusion</b>: increased BA diameter and PSV by less than 10% 15 sec and 1 min after cuff inflation indicate endothelial dysfunction. A negative pattern of changes in these parameters suggests an unfavorable course of preeclampsia and its transition to severe disease.
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<b>Keywords</b>: preeclampsia, e ndothelial dysfunction, vasodilation, brachial artery, peak systolic velocity, prognosis.
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<i><b>For citation: </b>Shavaeva R.Kh., Murashko A.V., Zuev V.M. et al. Predicting preeclampsia course based on endothelium-dependent dilation. Russian Journal of Woman and Child Health. 2021;4(4):317–321 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4-317-321.</i>
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| ISSN: | 2618-8430 2686-7184 |