Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy Controls
Condyloma acuminatum (CA) is a benign epithelium hyperplasia mainly caused by human papillomavirus (HPV), which is now the second most common viral sexually transmitted infection (STI) in China. In total, 90% of CA patients are caused by the low-risk HPV 6 and 11. Aside from low-risk HPV infection t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2019.00294/full |
| _version_ | 1828858494705467392 |
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| author | Yunying Zhou Yunying Zhou Yunying Zhou Lu Wang Fengyan Pei Mingyu Ji Fang Zhang Yingshuo Sun Qianqian Zhao Yatian Hong Xiao Wang Juanjuan Tian Yunshan Wang Yunshan Wang |
| author_facet | Yunying Zhou Yunying Zhou Yunying Zhou Lu Wang Fengyan Pei Mingyu Ji Fang Zhang Yingshuo Sun Qianqian Zhao Yatian Hong Xiao Wang Juanjuan Tian Yunshan Wang Yunshan Wang |
| author_sort | Yunying Zhou |
| collection | DOAJ |
| description | Condyloma acuminatum (CA) is a benign epithelium hyperplasia mainly caused by human papillomavirus (HPV), which is now the second most common viral sexually transmitted infection (STI) in China. In total, 90% of CA patients are caused by the low-risk HPV 6 and 11. Aside from low-risk HPV infection there are likely other factors within the local microenvironment that contribute to CA and there has been related research before. In this study, 62 vaginal specimens were analyzed using 16S rRNA gene sequencing. The diversity of the vaginal microbiota was higher and the composition was different with LR-HPV infection. While the relative abundance of dominant Firmicutes was lower, Actinobacteria, Proteobacteria, and Fusobacteria phyla were significantly higher; at the genus level Gardnerella, Bifidobacterium, Sneathia, Hydrogenophilus, Burkholderia, and Atopobium were higher. This study firstly confirmed a more accurate and comprehensive understanding of the relationship between low-risk HPV infection and vaginal microbiota, in order to provide a theoretical basis for further research on the occurrence and development of CA. |
| first_indexed | 2024-12-13T01:57:55Z |
| format | Article |
| id | doaj.art-a1f1addebb1c479999d1c62dbaf41637 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-13T01:57:55Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-a1f1addebb1c479999d1c62dbaf416372022-12-22T00:03:20ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882019-08-01910.3389/fcimb.2019.00294447025Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy ControlsYunying Zhou0Yunying Zhou1Yunying Zhou2Lu Wang3Fengyan Pei4Mingyu Ji5Fang Zhang6Yingshuo Sun7Qianqian Zhao8Yatian Hong9Xiao Wang10Juanjuan Tian11Yunshan Wang12Yunshan Wang13Medical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaShandong LaiBo Biotechnology Co., Ltd., Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaMedical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, ChinaCondyloma acuminatum (CA) is a benign epithelium hyperplasia mainly caused by human papillomavirus (HPV), which is now the second most common viral sexually transmitted infection (STI) in China. In total, 90% of CA patients are caused by the low-risk HPV 6 and 11. Aside from low-risk HPV infection there are likely other factors within the local microenvironment that contribute to CA and there has been related research before. In this study, 62 vaginal specimens were analyzed using 16S rRNA gene sequencing. The diversity of the vaginal microbiota was higher and the composition was different with LR-HPV infection. While the relative abundance of dominant Firmicutes was lower, Actinobacteria, Proteobacteria, and Fusobacteria phyla were significantly higher; at the genus level Gardnerella, Bifidobacterium, Sneathia, Hydrogenophilus, Burkholderia, and Atopobium were higher. This study firstly confirmed a more accurate and comprehensive understanding of the relationship between low-risk HPV infection and vaginal microbiota, in order to provide a theoretical basis for further research on the occurrence and development of CA.https://www.frontiersin.org/article/10.3389/fcimb.2019.00294/fulllow-risk HPVvaginal microbiome16S RNA sequencingcondyloma acuminatumsexually transmitted infections |
| spellingShingle | Yunying Zhou Yunying Zhou Yunying Zhou Lu Wang Fengyan Pei Mingyu Ji Fang Zhang Yingshuo Sun Qianqian Zhao Yatian Hong Xiao Wang Juanjuan Tian Yunshan Wang Yunshan Wang Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy Controls Frontiers in Cellular and Infection Microbiology low-risk HPV vaginal microbiome 16S RNA sequencing condyloma acuminatum sexually transmitted infections |
| title | Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy Controls |
| title_full | Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy Controls |
| title_fullStr | Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy Controls |
| title_full_unstemmed | Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy Controls |
| title_short | Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy Controls |
| title_sort | patients with lr hpv infection have a distinct vaginal microbiota in comparison with healthy controls |
| topic | low-risk HPV vaginal microbiome 16S RNA sequencing condyloma acuminatum sexually transmitted infections |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2019.00294/full |
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