MUC1 aptamer-tethered H40-TEPA-PEG nanoconjugates for targeted siRNA-delivery and gene silencing in breast cancer cells

MUC1 aptamer-tethered H40-TEPA-PEG nanoconjugates for targeted siRNA-delivery and gene silencing in breast cancer cells

With a prevalence of 12.5% of all new cancer cases annually, breast cancer stands as the most common form of cancer worldwide. The current therapies utilized for breast cancer are constrained and ineffective in addressing the condition. siRNA-based gene silencing is a promising method for treating b...

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Bibliographic Details
Main Authors: Rajesh Salve, Niladri Haldar, Aazam Shaikh, Rajkumar Samanta, Devyani Sengar, Surajit Patra, Virendra Gajbhiye
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
mucin-1
bis-MPA polyester
siRNA
survivin
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1383495/full

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