Brivaracetam to Treat Partial Onset Seizures in Adults
# Purpose of Review Seizures are a hyperexcitable, and hypersynchronous imbalance between excitatory and inhibitory factors (E/I imbalance) in neurotransmission, and epilepsy is the recurrent manifestation of seizures within a reasonable time frame and without being attributable to a reversible cau...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Open Medical Publishing
2023-01-01
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| Series: | Health Psychology Research |
| Online Access: | https://doi.org/10.52965/001c.56782 |
| _version_ | 1797341635050209280 |
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| author | Dustin Latimer David Le Evan Falgoust Patrick Ingraffia Alaa Abd-Elsayed Elyse M. Cornett Rupin Singh JooHee Choi Giustino Varrassi Adam M. Kaye Alan D. Kaye Latha Ganti |
| author_facet | Dustin Latimer David Le Evan Falgoust Patrick Ingraffia Alaa Abd-Elsayed Elyse M. Cornett Rupin Singh JooHee Choi Giustino Varrassi Adam M. Kaye Alan D. Kaye Latha Ganti |
| author_sort | Dustin Latimer |
| collection | DOAJ |
| description | # Purpose of Review
Seizures are a hyperexcitable, and hypersynchronous imbalance between excitatory and inhibitory factors (E/I imbalance) in neurotransmission, and epilepsy is the recurrent manifestation of seizures within a reasonable time frame and without being attributable to a reversible cause. Brivaracetam is a derivative of the antiepileptic agent, levetiracetam, that is used as adjuvant therapy for focal onset seizures. It was approved by the FDA in 2016 and has shown promising results with minimal adverse effect reactions in clinical trials.
# Recent Findings
Brivaracetam has been used in multiple clinical trials at various dosages in adults that have partial-onset seizures refractory to conventional treatment. A meta-analysis in 2016 showed that brivaracetam as adjunctive therapy was statically significant in its reduction of adults with drug-refractory seizure frequency.^1^ The most commonly reported adverse effects that patients who were taking brivaracetam experienced were somnolence, headache, and dizziness. Further studies are necessary to conclude long term efficacy and safety profile of brivaracetam.
# Conclusion
The treatment of epilepsy with pharmacologic agents is a difficult task due to balancing the efficacy of the drug with the side effect profile that will allow for the best quality of life for the patient. There are approximately 30 antiepileptic agents for clinicians to choose from. Brivaracetam is a novel antiepileptic agent that was approved for use by the FDA in 2016 and is showing promising results as monotherapy and adjunctive therapy in individuals with drug-refractory focal seizures while minimizing adverse drug reactions. |
| first_indexed | 2024-03-08T10:20:50Z |
| format | Article |
| id | doaj.art-a1f248dd9137472d8d47e587386dc7f8 |
| institution | Directory Open Access Journal |
| issn | 2420-8124 |
| language | English |
| last_indexed | 2024-03-08T10:20:50Z |
| publishDate | 2023-01-01 |
| publisher | Open Medical Publishing |
| record_format | Article |
| series | Health Psychology Research |
| spelling | doaj.art-a1f248dd9137472d8d47e587386dc7f82024-01-27T23:14:29ZengOpen Medical PublishingHealth Psychology Research2420-81242023-01-01105Brivaracetam to Treat Partial Onset Seizures in AdultsDustin LatimerDavid LeEvan FalgoustPatrick IngraffiaAlaa Abd-ElsayedElyse M. CornettRupin SinghJooHee ChoiGiustino VarrassiAdam M. KayeAlan D. KayeLatha Ganti# Purpose of Review Seizures are a hyperexcitable, and hypersynchronous imbalance between excitatory and inhibitory factors (E/I imbalance) in neurotransmission, and epilepsy is the recurrent manifestation of seizures within a reasonable time frame and without being attributable to a reversible cause. Brivaracetam is a derivative of the antiepileptic agent, levetiracetam, that is used as adjuvant therapy for focal onset seizures. It was approved by the FDA in 2016 and has shown promising results with minimal adverse effect reactions in clinical trials. # Recent Findings Brivaracetam has been used in multiple clinical trials at various dosages in adults that have partial-onset seizures refractory to conventional treatment. A meta-analysis in 2016 showed that brivaracetam as adjunctive therapy was statically significant in its reduction of adults with drug-refractory seizure frequency.^1^ The most commonly reported adverse effects that patients who were taking brivaracetam experienced were somnolence, headache, and dizziness. Further studies are necessary to conclude long term efficacy and safety profile of brivaracetam. # Conclusion The treatment of epilepsy with pharmacologic agents is a difficult task due to balancing the efficacy of the drug with the side effect profile that will allow for the best quality of life for the patient. There are approximately 30 antiepileptic agents for clinicians to choose from. Brivaracetam is a novel antiepileptic agent that was approved for use by the FDA in 2016 and is showing promising results as monotherapy and adjunctive therapy in individuals with drug-refractory focal seizures while minimizing adverse drug reactions.https://doi.org/10.52965/001c.56782 |
| spellingShingle | Dustin Latimer David Le Evan Falgoust Patrick Ingraffia Alaa Abd-Elsayed Elyse M. Cornett Rupin Singh JooHee Choi Giustino Varrassi Adam M. Kaye Alan D. Kaye Latha Ganti Brivaracetam to Treat Partial Onset Seizures in Adults Health Psychology Research |
| title | Brivaracetam to Treat Partial Onset Seizures in Adults |
| title_full | Brivaracetam to Treat Partial Onset Seizures in Adults |
| title_fullStr | Brivaracetam to Treat Partial Onset Seizures in Adults |
| title_full_unstemmed | Brivaracetam to Treat Partial Onset Seizures in Adults |
| title_short | Brivaracetam to Treat Partial Onset Seizures in Adults |
| title_sort | brivaracetam to treat partial onset seizures in adults |
| url | https://doi.org/10.52965/001c.56782 |
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