On the feasibility of the computational modelling of the endoluminal vacuum-assisted closure of an oesophageal anastomotic leakage
Endoluminal vacuum-assisted closure (E-VAC) is a promising therapy to treat anastomotic leakages of the oesophagus and bowel which are associated with high morbidity and mortality rates. An open-pore polyurethane foam is introduced into the leakage cavity and connected to a device that applies a suc...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2018-01-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171289 |
| _version_ | 1818324699606679552 |
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| author | Ester Comellas Facundo J. Bellomo Iván Rosales Luis F. del Castillo Ricardo Sánchez Pau Turon Sergio Oller |
| author_facet | Ester Comellas Facundo J. Bellomo Iván Rosales Luis F. del Castillo Ricardo Sánchez Pau Turon Sergio Oller |
| author_sort | Ester Comellas |
| collection | DOAJ |
| description | Endoluminal vacuum-assisted closure (E-VAC) is a promising therapy to treat anastomotic leakages of the oesophagus and bowel which are associated with high morbidity and mortality rates. An open-pore polyurethane foam is introduced into the leakage cavity and connected to a device that applies a suction pressure to accelerate the closure of the defect. Computational analysis of this healing process can advance our understanding of the biomechanical mechanisms at play. To this aim, we use a dual-stage finite-element analysis in which (i) the structural problem addresses the cavity reduction caused by the suction and (ii) a new constitutive formulation models tissue healing via permanent deformations coupled to a stiffness increase. The numerical implementation in an in-house code is described and a qualitative example illustrates the basic characteristics of the model. The computational model successfully reproduces the generic closure of an anastomotic leakage cavity, supporting the hypothesis that suction pressure promotes healing by means of the aforementioned mechanisms. However, the current framework needs to be enriched with empirical data to help advance device designs and treatment guidelines. Nonetheless, this conceptual study confirms that computational analysis can reproduce E-VAC of anastomotic leakages and establishes the bases for better understanding the mechanobiology of anastomotic defect healing. |
| first_indexed | 2024-12-13T11:32:44Z |
| format | Article |
| id | doaj.art-a1f313ed07024ba584a93a246f3d7b6e |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-13T11:32:44Z |
| publishDate | 2018-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-a1f313ed07024ba584a93a246f3d7b6e2022-12-21T23:47:53ZengThe Royal SocietyRoyal Society Open Science2054-57032018-01-015210.1098/rsos.171289171289On the feasibility of the computational modelling of the endoluminal vacuum-assisted closure of an oesophageal anastomotic leakageEster ComellasFacundo J. BellomoIván RosalesLuis F. del CastilloRicardo SánchezPau TuronSergio OllerEndoluminal vacuum-assisted closure (E-VAC) is a promising therapy to treat anastomotic leakages of the oesophagus and bowel which are associated with high morbidity and mortality rates. An open-pore polyurethane foam is introduced into the leakage cavity and connected to a device that applies a suction pressure to accelerate the closure of the defect. Computational analysis of this healing process can advance our understanding of the biomechanical mechanisms at play. To this aim, we use a dual-stage finite-element analysis in which (i) the structural problem addresses the cavity reduction caused by the suction and (ii) a new constitutive formulation models tissue healing via permanent deformations coupled to a stiffness increase. The numerical implementation in an in-house code is described and a qualitative example illustrates the basic characteristics of the model. The computational model successfully reproduces the generic closure of an anastomotic leakage cavity, supporting the hypothesis that suction pressure promotes healing by means of the aforementioned mechanisms. However, the current framework needs to be enriched with empirical data to help advance device designs and treatment guidelines. Nonetheless, this conceptual study confirms that computational analysis can reproduce E-VAC of anastomotic leakages and establishes the bases for better understanding the mechanobiology of anastomotic defect healing.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171289endoluminal vacuum-assisted closurehealinggrowthfinite-element analysisconstitutive modelling |
| spellingShingle | Ester Comellas Facundo J. Bellomo Iván Rosales Luis F. del Castillo Ricardo Sánchez Pau Turon Sergio Oller On the feasibility of the computational modelling of the endoluminal vacuum-assisted closure of an oesophageal anastomotic leakage Royal Society Open Science endoluminal vacuum-assisted closure healing growth finite-element analysis constitutive modelling |
| title | On the feasibility of the computational modelling of the endoluminal vacuum-assisted closure of an oesophageal anastomotic leakage |
| title_full | On the feasibility of the computational modelling of the endoluminal vacuum-assisted closure of an oesophageal anastomotic leakage |
| title_fullStr | On the feasibility of the computational modelling of the endoluminal vacuum-assisted closure of an oesophageal anastomotic leakage |
| title_full_unstemmed | On the feasibility of the computational modelling of the endoluminal vacuum-assisted closure of an oesophageal anastomotic leakage |
| title_short | On the feasibility of the computational modelling of the endoluminal vacuum-assisted closure of an oesophageal anastomotic leakage |
| title_sort | on the feasibility of the computational modelling of the endoluminal vacuum assisted closure of an oesophageal anastomotic leakage |
| topic | endoluminal vacuum-assisted closure healing growth finite-element analysis constitutive modelling |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171289 |
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