Association of rs12722 COL5A1gene variation with risk of anterior cruciate ligament rupture
Objective: to determine the influence of rs12722 (C/T)COL5A1 gene variation on ACL rupture in Europeans of Ural region of Russia. Materials and methods: the case group included 173 patients with diagnosed anterior cruciate ligament (ACL) ruptures; control group included 370 asymptomatic persons. Bot...
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National Electronic Information Consortium (NEICON)
2020-08-01
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| Series: | Спортивная медицина: наука и практика |
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| Online Access: | https://www.smjournal.ru/jour/article/view/80 |
| _version_ | 1797372528719560704 |
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| author | V. Pushkarev D. Dyatlov R. Akhmetyanov A. Chmutov Y. Pushkareva L. Pollyak |
| author_facet | V. Pushkarev D. Dyatlov R. Akhmetyanov A. Chmutov Y. Pushkareva L. Pollyak |
| author_sort | V. Pushkarev |
| collection | DOAJ |
| description | Objective: to determine the influence of rs12722 (C/T)COL5A1 gene variation on ACL rupture in Europeans of Ural region of Russia. Materials and methods: the case group included 173 patients with diagnosed anterior cruciate ligament (ACL) ruptures; control group included 370 asymptomatic persons. Both groups were similar on a sex, age, growth, weight and BMI. Results: the following genotypic frequencies were observed (in %): case group - a T/T of 34,1, C/T of 46,8, C/C of 19,1; control group - a T/T of 25,4, C/T of 50,8, C/C 23,8. Genotypic frequencies in both groups met Hardy-Weinberg equilibrium. Significant difference of allelic frequencies was revealed between two groups (p = 0,039). Persons with a T/T genotype had a significantly increased risk of ACL ruptures in comparison with persons with C/T + C/C genotypes (x2 = 4,408, p = 0,036, OR = 1,52, 95% confidence interval: 1,027 - 2,249). Conclusions: this is the first study that shown the association of rs12722 COL5A1 gene variation with risk of an ACL rupture in Russian population. |
| first_indexed | 2024-03-08T18:37:09Z |
| format | Article |
| id | doaj.art-a1f368dcc02c4e7980db198f2894d636 |
| institution | Directory Open Access Journal |
| issn | 2223-2524 2587-9014 |
| language | English |
| last_indexed | 2024-03-08T18:37:09Z |
| publishDate | 2020-08-01 |
| publisher | National Electronic Information Consortium (NEICON) |
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| series | Спортивная медицина: наука и практика |
| spelling | doaj.art-a1f368dcc02c4e7980db198f2894d6362023-12-29T11:27:46ZengNational Electronic Information Consortium (NEICON)Спортивная медицина: наука и практика2223-25242587-90142020-08-0174636810.17238/ISSN2223-2524.2017.4.6379Association of rs12722 COL5A1gene variation with risk of anterior cruciate ligament ruptureV. Pushkarev0D. Dyatlov1R. Akhmetyanov2A. Chmutov3Y. Pushkareva4L. Pollyak5ФГБОУ ВО Южно-Уральский Государственный медицинский университет Минздрава России; ФГБУН Уральский научно-практический центр радиационной медицины ФМБА РоссииФГБОУ ВО Уральский Государственный университет физической культуры Минспорта РоссииГБУЗ Челябинская областная клиническая больница Минздрава Челябинской областиМедицинский центр «МЕДЕОР»ФГБОУ ВО Южно-Уральский Государственный медицинский университет Минздрава РоссииГБУЗ Челябинская областная клиническая больница Минздрава Челябинской областиObjective: to determine the influence of rs12722 (C/T)COL5A1 gene variation on ACL rupture in Europeans of Ural region of Russia. Materials and methods: the case group included 173 patients with diagnosed anterior cruciate ligament (ACL) ruptures; control group included 370 asymptomatic persons. Both groups were similar on a sex, age, growth, weight and BMI. Results: the following genotypic frequencies were observed (in %): case group - a T/T of 34,1, C/T of 46,8, C/C of 19,1; control group - a T/T of 25,4, C/T of 50,8, C/C 23,8. Genotypic frequencies in both groups met Hardy-Weinberg equilibrium. Significant difference of allelic frequencies was revealed between two groups (p = 0,039). Persons with a T/T genotype had a significantly increased risk of ACL ruptures in comparison with persons with C/T + C/C genotypes (x2 = 4,408, p = 0,036, OR = 1,52, 95% confidence interval: 1,027 - 2,249). Conclusions: this is the first study that shown the association of rs12722 COL5A1 gene variation with risk of an ACL rupture in Russian population.https://www.smjournal.ru/jour/article/view/803'-нетранслируемая областьanterior cruciate ligament rupturegenetic predispositioncol5a1 genesequence variation rs12722 (c/t)3'-untranslated region |
| spellingShingle | V. Pushkarev D. Dyatlov R. Akhmetyanov A. Chmutov Y. Pushkareva L. Pollyak Association of rs12722 COL5A1gene variation with risk of anterior cruciate ligament rupture Спортивная медицина: наука и практика 3'-нетранслируемая область anterior cruciate ligament rupture genetic predisposition col5a1 gene sequence variation rs12722 (c/t) 3'-untranslated region |
| title | Association of rs12722 COL5A1gene variation with risk of anterior cruciate ligament rupture |
| title_full | Association of rs12722 COL5A1gene variation with risk of anterior cruciate ligament rupture |
| title_fullStr | Association of rs12722 COL5A1gene variation with risk of anterior cruciate ligament rupture |
| title_full_unstemmed | Association of rs12722 COL5A1gene variation with risk of anterior cruciate ligament rupture |
| title_short | Association of rs12722 COL5A1gene variation with risk of anterior cruciate ligament rupture |
| title_sort | association of rs12722 col5a1gene variation with risk of anterior cruciate ligament rupture |
| topic | 3'-нетранслируемая область anterior cruciate ligament rupture genetic predisposition col5a1 gene sequence variation rs12722 (c/t) 3'-untranslated region |
| url | https://www.smjournal.ru/jour/article/view/80 |
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