3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers
Currently, the number of approved veterinary medicines are limited, and human medications are used off-label. These approved human medications are of too high potencies for a cat or a small dog breed. Therefore, there is a dire demand for smaller doses of veterinary medicines. This study aims to inv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/12/1239 |
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| author | Erica Sjöholm Rathna Mathiyalagan Dhayakumar Rajan Prakash Lisa Lindfors Qingbo Wang Xiaoju Wang Samuli Ojala Niklas Sandler |
| author_facet | Erica Sjöholm Rathna Mathiyalagan Dhayakumar Rajan Prakash Lisa Lindfors Qingbo Wang Xiaoju Wang Samuli Ojala Niklas Sandler |
| author_sort | Erica Sjöholm |
| collection | DOAJ |
| description | Currently, the number of approved veterinary medicines are limited, and human medications are used off-label. These approved human medications are of too high potencies for a cat or a small dog breed. Therefore, there is a dire demand for smaller doses of veterinary medicines. This study aims to investigate the use of three semi-solid extrusion 3D printers in a pharmacy or animal clinic setting for the extemporaneous manufacturing of prednisolone containing orodispersible films for veterinary use. Orodispersible films with adequate content uniformity and acceptance values as defined by the European Pharmacopoeia were produced with one of the studied printers, namely the Allevi 2 bioprinter. Smooth and flexible films with high mechanical strength, neutral pH, and low moisture content were produced with a high correlation between the prepared design and the obtained drug amount, indicating that the Allevi 2 printer could successfully be used to extemporaneously manufacture personalized doses for animals at the point-of-care. |
| first_indexed | 2024-03-10T13:55:23Z |
| format | Article |
| id | doaj.art-a1f45eb24eab49deb27b360700b832c7 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T13:55:23Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a1f45eb24eab49deb27b360700b832c72023-11-21T01:39:23ZengMDPI AGPharmaceutics1999-49232020-12-011212123910.3390/pharmaceutics121212393D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D PrintersErica Sjöholm0Rathna Mathiyalagan1Dhayakumar Rajan Prakash2Lisa Lindfors3Qingbo Wang4Xiaoju Wang5Samuli Ojala6Niklas Sandler7Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, FinlandPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, FinlandPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, FinlandPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, FinlandJohan Gadolin Process Chemistry Centre, Åbo Akademi University, Piispankatu 8, 20500 Turku, FinlandPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, FinlandOulun Keskus Apteekki, Isokatu 45, 90100 Oulu, FinlandPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, FinlandCurrently, the number of approved veterinary medicines are limited, and human medications are used off-label. These approved human medications are of too high potencies for a cat or a small dog breed. Therefore, there is a dire demand for smaller doses of veterinary medicines. This study aims to investigate the use of three semi-solid extrusion 3D printers in a pharmacy or animal clinic setting for the extemporaneous manufacturing of prednisolone containing orodispersible films for veterinary use. Orodispersible films with adequate content uniformity and acceptance values as defined by the European Pharmacopoeia were produced with one of the studied printers, namely the Allevi 2 bioprinter. Smooth and flexible films with high mechanical strength, neutral pH, and low moisture content were produced with a high correlation between the prepared design and the obtained drug amount, indicating that the Allevi 2 printer could successfully be used to extemporaneously manufacture personalized doses for animals at the point-of-care.https://www.mdpi.com/1999-4923/12/12/12393D printingsemi-solid extrusion 3D printingadditive manufacturingextemporaneous manufacturingdrug deliverypersonalized dosage forms |
| spellingShingle | Erica Sjöholm Rathna Mathiyalagan Dhayakumar Rajan Prakash Lisa Lindfors Qingbo Wang Xiaoju Wang Samuli Ojala Niklas Sandler 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers Pharmaceutics 3D printing semi-solid extrusion 3D printing additive manufacturing extemporaneous manufacturing drug delivery personalized dosage forms |
| title | 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers |
| title_full | 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers |
| title_fullStr | 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers |
| title_full_unstemmed | 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers |
| title_short | 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers |
| title_sort | 3d printed veterinary dosage forms a comparative study of three semi solid extrusion 3d printers |
| topic | 3D printing semi-solid extrusion 3D printing additive manufacturing extemporaneous manufacturing drug delivery personalized dosage forms |
| url | https://www.mdpi.com/1999-4923/12/12/1239 |
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