The applications and potential limitations of right ventricular volumes as surrogate marker in tetralogy of fallot
Cardiac magnetic resonance imaging derived right ventricular (RV) volumes are often necessary for optimal timing of pulmonary valve replacement in patients with tetralogy of Fallot (TOF). This practice is based on previous studies that reported preoperative RV volumetric thresholds that predicted po...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906719301939 |
| _version_ | 1819227437268992000 |
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| author | Alexander C. Egbe Keerthana Banala Rahul Vojjini Karim Osman Arslan Afzal Vaibhav Jain Sahith Thotamgari Naser M. Ammash |
| author_facet | Alexander C. Egbe Keerthana Banala Rahul Vojjini Karim Osman Arslan Afzal Vaibhav Jain Sahith Thotamgari Naser M. Ammash |
| author_sort | Alexander C. Egbe |
| collection | DOAJ |
| description | Cardiac magnetic resonance imaging derived right ventricular (RV) volumes are often necessary for optimal timing of pulmonary valve replacement in patients with tetralogy of Fallot (TOF). This practice is based on previous studies that reported preoperative RV volumetric thresholds that predicted postoperative RV remodeling. As a result, pulmonary valve replacements are being performed even in asymptomatic patients based on RV volumetric thresholds that predict complete postoperative RVOT remodeling. Hence, RV volumes are now being used as surrogate markers/endpoints for future cardiovascular outcomes. Unfortunately, there are no studies showing survival benefit for performing pulmonary valve replacement at smaller RV volumes. This review underscores some of the limitations of using RV volumes as surrogate markers for clinical outcomes, and also highlights knowledge gaps about the pathophysiologic mechanism of cardiovascular death in the TOF population. Keywords: Right ventricular volumes, Tetralogy of fallot, Cardiovascular mortality |
| first_indexed | 2024-12-23T10:41:22Z |
| format | Article |
| id | doaj.art-a1f61cd28e8641b88825a689d7eecbbd |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-23T10:41:22Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-a1f61cd28e8641b88825a689d7eecbbd2022-12-21T17:50:09ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672020-02-0126The applications and potential limitations of right ventricular volumes as surrogate marker in tetralogy of fallotAlexander C. Egbe0Keerthana Banala1Rahul Vojjini2Karim Osman3Arslan Afzal4Vaibhav Jain5Sahith Thotamgari6Naser M. Ammash7Corresponding author at: Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, United States.; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, United StatesCardiac magnetic resonance imaging derived right ventricular (RV) volumes are often necessary for optimal timing of pulmonary valve replacement in patients with tetralogy of Fallot (TOF). This practice is based on previous studies that reported preoperative RV volumetric thresholds that predicted postoperative RV remodeling. As a result, pulmonary valve replacements are being performed even in asymptomatic patients based on RV volumetric thresholds that predict complete postoperative RVOT remodeling. Hence, RV volumes are now being used as surrogate markers/endpoints for future cardiovascular outcomes. Unfortunately, there are no studies showing survival benefit for performing pulmonary valve replacement at smaller RV volumes. This review underscores some of the limitations of using RV volumes as surrogate markers for clinical outcomes, and also highlights knowledge gaps about the pathophysiologic mechanism of cardiovascular death in the TOF population. Keywords: Right ventricular volumes, Tetralogy of fallot, Cardiovascular mortalityhttp://www.sciencedirect.com/science/article/pii/S2352906719301939 |
| spellingShingle | Alexander C. Egbe Keerthana Banala Rahul Vojjini Karim Osman Arslan Afzal Vaibhav Jain Sahith Thotamgari Naser M. Ammash The applications and potential limitations of right ventricular volumes as surrogate marker in tetralogy of fallot International Journal of Cardiology: Heart & Vasculature |
| title | The applications and potential limitations of right ventricular volumes as surrogate marker in tetralogy of fallot |
| title_full | The applications and potential limitations of right ventricular volumes as surrogate marker in tetralogy of fallot |
| title_fullStr | The applications and potential limitations of right ventricular volumes as surrogate marker in tetralogy of fallot |
| title_full_unstemmed | The applications and potential limitations of right ventricular volumes as surrogate marker in tetralogy of fallot |
| title_short | The applications and potential limitations of right ventricular volumes as surrogate marker in tetralogy of fallot |
| title_sort | applications and potential limitations of right ventricular volumes as surrogate marker in tetralogy of fallot |
| url | http://www.sciencedirect.com/science/article/pii/S2352906719301939 |
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