Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

Nonstructural protein 5 (Nsp5) is the main protease of SARS-CoV-2 that cleaves viral polyproteins into individual polypeptides necessary for viral replication. Here, we show that Nsp5 binds and cleaves human tRNA methyltransferase 1 (TRMT1), a host enzyme required for a prevalent post-transcriptiona...

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Bibliographic Details
Main Authors: Kejia Zhang, Patrick Eldin, Jessica H Ciesla, Laurence Briant, Jenna M Lentini, Jillian Ramos, Justin Cobb, Joshua Munger, Dragony Fu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-05-01
Series:eLife
Subjects:
SARS-CoV-2
coronavirus
tRNA
TRMT1
Nsp5
main protease
Online Access:https://elifesciences.org/articles/90316

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