Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis
Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment. Despite of the serious effort that has been applied to develop effective antitubercular chemotherapies, the potential of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01499/full |
| _version_ | 1819128581116133376 |
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| author | Javier Arranz-Trullén Javier Arranz-Trullén Lu Lu David Pulido Sanjib Bhakta Ester Boix |
| author_facet | Javier Arranz-Trullén Javier Arranz-Trullén Lu Lu David Pulido Sanjib Bhakta Ester Boix |
| author_sort | Javier Arranz-Trullén |
| collection | DOAJ |
| description | Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment. Despite of the serious effort that has been applied to develop effective antitubercular chemotherapies, the potential of antimicrobial peptides (AMPs) remains underexploited. A large amount of literature is now accessible on the AMP mechanisms of action against a diversity of pathogens; nevertheless, research on their activity on mycobacteria is still scarce. In particular, there is an urgent need to integrate all available interdisciplinary strategies to eradicate extensively drug-resistant Mycobacterium tuberculosis strains. In this context, we should not underestimate our endogenous antimicrobial proteins and peptides as ancient players of the human host defense system. We are confident that novel antibiotics based on human AMPs displaying a rapid and multifaceted mechanism, with reduced toxicity, should significantly contribute to reverse the tide of antimycobacterial drug resistance. In this review, we have provided an up to date perspective of the current research on AMPs to be applied in the fight against TB. A better understanding on the mechanisms of action of human endogenous peptides should ensure the basis for the best guided design of novel antitubercular chemotherapeutics. |
| first_indexed | 2024-12-22T08:30:06Z |
| format | Article |
| id | doaj.art-a1f70a23d43242729c5e72e7516ac62c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T08:30:06Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a1f70a23d43242729c5e72e7516ac62c2022-12-21T18:32:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-11-01810.3389/fimmu.2017.01499276303Host Antimicrobial Peptides: The Promise of New Treatment Strategies against TuberculosisJavier Arranz-Trullén0Javier Arranz-Trullén1Lu Lu2David Pulido3Sanjib Bhakta4Ester Boix5Faculty of Biosciences, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, SpainMycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck University of London, London, United KingdomFaculty of Biosciences, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, SpainFaculty of Biosciences, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, SpainMycobacteria Research Laboratory, Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck University of London, London, United KingdomFaculty of Biosciences, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, SpainTuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment. Despite of the serious effort that has been applied to develop effective antitubercular chemotherapies, the potential of antimicrobial peptides (AMPs) remains underexploited. A large amount of literature is now accessible on the AMP mechanisms of action against a diversity of pathogens; nevertheless, research on their activity on mycobacteria is still scarce. In particular, there is an urgent need to integrate all available interdisciplinary strategies to eradicate extensively drug-resistant Mycobacterium tuberculosis strains. In this context, we should not underestimate our endogenous antimicrobial proteins and peptides as ancient players of the human host defense system. We are confident that novel antibiotics based on human AMPs displaying a rapid and multifaceted mechanism, with reduced toxicity, should significantly contribute to reverse the tide of antimycobacterial drug resistance. In this review, we have provided an up to date perspective of the current research on AMPs to be applied in the fight against TB. A better understanding on the mechanisms of action of human endogenous peptides should ensure the basis for the best guided design of novel antitubercular chemotherapeutics.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01499/fullantimicrobial peptidesinnate immunitytuberculosisinfectious diseasesmycobacteriaantimicrobial resistance |
| spellingShingle | Javier Arranz-Trullén Javier Arranz-Trullén Lu Lu David Pulido Sanjib Bhakta Ester Boix Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis Frontiers in Immunology antimicrobial peptides innate immunity tuberculosis infectious diseases mycobacteria antimicrobial resistance |
| title | Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis |
| title_full | Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis |
| title_fullStr | Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis |
| title_full_unstemmed | Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis |
| title_short | Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis |
| title_sort | host antimicrobial peptides the promise of new treatment strategies against tuberculosis |
| topic | antimicrobial peptides innate immunity tuberculosis infectious diseases mycobacteria antimicrobial resistance |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01499/full |
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