Ribosome-Directed Therapies in Cancer
The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome bi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2088 |
| _version_ | 1827663270965673984 |
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| author | Gazmend Temaj Silvia Chichiarelli Margherita Eufemi Fabio Altieri Rifat Hadziselimovic Ammad Ahmad Farooqi Ilhan Yaylim Luciano Saso |
| author_facet | Gazmend Temaj Silvia Chichiarelli Margherita Eufemi Fabio Altieri Rifat Hadziselimovic Ammad Ahmad Farooqi Ilhan Yaylim Luciano Saso |
| author_sort | Gazmend Temaj |
| collection | DOAJ |
| description | The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome biogenesis and mutation of ribosomal proteins. The ribosome represents an attractive anti-cancer therapy target and several strategies are used to identify specific drugs. Here we review the role of different drugs that may decrease ribosome biogenesis and cancer cell proliferation. |
| first_indexed | 2024-03-10T00:40:32Z |
| format | Article |
| id | doaj.art-a1f97a94b58049e28327427ca3b58927 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:40:32Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a1f97a94b58049e28327427ca3b589272023-11-23T15:08:57ZengMDPI AGBiomedicines2227-90592022-08-01109208810.3390/biomedicines10092088Ribosome-Directed Therapies in CancerGazmend Temaj0Silvia Chichiarelli1Margherita Eufemi2Fabio Altieri3Rifat Hadziselimovic4Ammad Ahmad Farooqi5Ilhan Yaylim6Luciano Saso7Faculty of Pharmacy, College UBT, 10000 Prishtina, KosovoDepartment of Biochemical Sciences “A.Rossi-Fanelli”, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Biochemical Sciences “A.Rossi-Fanelli”, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Biochemical Sciences “A.Rossi-Fanelli”, Sapienza University of Rome, 00185 Rome, ItalyFaculty of Science, University of Sarajevo, 71000 Sarajevo, Bosnia and HerzegovinaInstitute of Biomedical and Genetic Engineering (IBGE), Islamabad 54000, PakistanDepartment of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Çapa, Istanbul 34280, TurkeyDepartment of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, 00185 Rome, ItalyThe human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome biogenesis and mutation of ribosomal proteins. The ribosome represents an attractive anti-cancer therapy target and several strategies are used to identify specific drugs. Here we review the role of different drugs that may decrease ribosome biogenesis and cancer cell proliferation.https://www.mdpi.com/2227-9059/10/9/2088ribosomecancertarget drugsrRNA and tRNA inhibition |
| spellingShingle | Gazmend Temaj Silvia Chichiarelli Margherita Eufemi Fabio Altieri Rifat Hadziselimovic Ammad Ahmad Farooqi Ilhan Yaylim Luciano Saso Ribosome-Directed Therapies in Cancer Biomedicines ribosome cancer target drugs rRNA and tRNA inhibition |
| title | Ribosome-Directed Therapies in Cancer |
| title_full | Ribosome-Directed Therapies in Cancer |
| title_fullStr | Ribosome-Directed Therapies in Cancer |
| title_full_unstemmed | Ribosome-Directed Therapies in Cancer |
| title_short | Ribosome-Directed Therapies in Cancer |
| title_sort | ribosome directed therapies in cancer |
| topic | ribosome cancer target drugs rRNA and tRNA inhibition |
| url | https://www.mdpi.com/2227-9059/10/9/2088 |
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