XPF activates break-induced telomere synthesis
Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend their telomeres independent of telomerase.
Bibliographic Details
| Main Authors: |
Chia-Yu Guh,
Hong-Jhih Shen,
Liv WeiChien Chen,
Pei-Chen Chiu,
I-Hsin Liao,
Chen-Chia Lo,
Yunfei Chen,
Yu-Hung Hsieh,
Ting-Chia Chang,
Chien-Ping Yen,
Yi-Yun Chen,
Tom Wei-Wu Chen,
Liuh-Yow Chen,
Ching-Shyi Wu,
Jean-Marc Egly,
Hsueh-Ping Catherine Chu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-33428-0
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