Fragmented Sleep and the Prevalence of Hypertension in Middle-Aged and Older Individuals
Juan Zhao,1 Wenjuan Wang,1 Suhua Wei,1 Lihong Yang,2 Yanhua Wu,2 Bin Yan2,3 1Department of Haematology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Clinical Research Center, the First Affiliated Hospital of Xi’an Jiaotong University,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-12-01
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| Series: | Nature and Science of Sleep |
| Subjects: | |
| Online Access: | https://www.dovepress.com/fragmented-sleep-and-the-prevalence-of-hypertension-in-middle-aged-and-peer-reviewed-fulltext-article-NSS |
| _version_ | 1818365715733807104 |
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| author | Zhao J Wang W Wei S Yang L Wu Y Yan B |
| author_facet | Zhao J Wang W Wei S Yang L Wu Y Yan B |
| author_sort | Zhao J |
| collection | DOAJ |
| description | Juan Zhao,1 Wenjuan Wang,1 Suhua Wei,1 Lihong Yang,2 Yanhua Wu,2 Bin Yan2,3 1Department of Haematology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Clinical Research Center, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 3Department of Psychiatry, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaCorrespondence: Bin YanDepartment of Clinical Research Center, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaTel +86 02985323614Email yanbin.1987@hotmail.comObjective: We aimed to investigate the association between fragmented sleep and the prevalence of hypertension in middle-aged and older individuals.Methods: This study included 5804 participants with an average age of 63.1± 11.2 years from the Sleep Heart Health Study. Fragmented sleep parameters including arousal index in total sleep (ArI-Total), rapid eye movement sleep (ArI-REM), non-rapid eye movement sleep (ArI-NREM), fragmented sleep index (SFI), sleep efficiency (SE) and wake after sleep onset (WASO) were monitored using polysomnography. The information on hypertension, defined as systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg or under antihypertensive treatment, was collected at baseline. We conducted multivariable logistic regression to explore the cross-sectional association between fragmented sleep and the prevalence of hypertension.Results: After adjusting for potential confounders, fragmented sleep parameters (per 5-unit change) including SE (odds ratio [OR] 0.904; 95% confidence interval [CI] 0.877– 0.932; P < 0.001), WASO (OR 1.019; 95% CI 1.012– 1.027; P < 0.001), ArI-Total (OR, 1.036; 95% CI, 1.005– 1.068; P = 0.024), and ArI-NREM (OR 1.032; 95% CI 1.004– 1.062; P = 0.027) were significantly associated with the prevalence of hypertension. In addition, ArI-Total, ArI-NREM, and ArI-REM were positively correlated with both systolic blood pressure and diastolic blood pressure.Conclusion: We found a high prevalence of hypertension among middle-aged and older individuals with fragmented sleep. The causal association between fragmented sleep and hypertension warrants further investigation.Keywords: blood pressure, polysomnography, fragmented sleep, Sleep Heart Health Study, cross-sectional study |
| first_indexed | 2024-12-13T22:24:40Z |
| format | Article |
| id | doaj.art-a1fbf6aa0c03407f80f85f75cf1ef1f1 |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-12-13T22:24:40Z |
| publishDate | 2021-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-a1fbf6aa0c03407f80f85f75cf1ef1f12022-12-21T23:29:16ZengDove Medical PressNature and Science of Sleep1179-16082021-12-01Volume 132273228071883Fragmented Sleep and the Prevalence of Hypertension in Middle-Aged and Older IndividualsZhao JWang WWei SYang LWu YYan BJuan Zhao,1 Wenjuan Wang,1 Suhua Wei,1 Lihong Yang,2 Yanhua Wu,2 Bin Yan2,3 1Department of Haematology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Clinical Research Center, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 3Department of Psychiatry, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaCorrespondence: Bin YanDepartment of Clinical Research Center, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaTel +86 02985323614Email yanbin.1987@hotmail.comObjective: We aimed to investigate the association between fragmented sleep and the prevalence of hypertension in middle-aged and older individuals.Methods: This study included 5804 participants with an average age of 63.1± 11.2 years from the Sleep Heart Health Study. Fragmented sleep parameters including arousal index in total sleep (ArI-Total), rapid eye movement sleep (ArI-REM), non-rapid eye movement sleep (ArI-NREM), fragmented sleep index (SFI), sleep efficiency (SE) and wake after sleep onset (WASO) were monitored using polysomnography. The information on hypertension, defined as systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg or under antihypertensive treatment, was collected at baseline. We conducted multivariable logistic regression to explore the cross-sectional association between fragmented sleep and the prevalence of hypertension.Results: After adjusting for potential confounders, fragmented sleep parameters (per 5-unit change) including SE (odds ratio [OR] 0.904; 95% confidence interval [CI] 0.877– 0.932; P < 0.001), WASO (OR 1.019; 95% CI 1.012– 1.027; P < 0.001), ArI-Total (OR, 1.036; 95% CI, 1.005– 1.068; P = 0.024), and ArI-NREM (OR 1.032; 95% CI 1.004– 1.062; P = 0.027) were significantly associated with the prevalence of hypertension. In addition, ArI-Total, ArI-NREM, and ArI-REM were positively correlated with both systolic blood pressure and diastolic blood pressure.Conclusion: We found a high prevalence of hypertension among middle-aged and older individuals with fragmented sleep. The causal association between fragmented sleep and hypertension warrants further investigation.Keywords: blood pressure, polysomnography, fragmented sleep, Sleep Heart Health Study, cross-sectional studyhttps://www.dovepress.com/fragmented-sleep-and-the-prevalence-of-hypertension-in-middle-aged-and-peer-reviewed-fulltext-article-NSSblood pressurepolysomnographyfragmented sleepsleep heart health studycross-sectional study |
| spellingShingle | Zhao J Wang W Wei S Yang L Wu Y Yan B Fragmented Sleep and the Prevalence of Hypertension in Middle-Aged and Older Individuals Nature and Science of Sleep blood pressure polysomnography fragmented sleep sleep heart health study cross-sectional study |
| title | Fragmented Sleep and the Prevalence of Hypertension in Middle-Aged and Older Individuals |
| title_full | Fragmented Sleep and the Prevalence of Hypertension in Middle-Aged and Older Individuals |
| title_fullStr | Fragmented Sleep and the Prevalence of Hypertension in Middle-Aged and Older Individuals |
| title_full_unstemmed | Fragmented Sleep and the Prevalence of Hypertension in Middle-Aged and Older Individuals |
| title_short | Fragmented Sleep and the Prevalence of Hypertension in Middle-Aged and Older Individuals |
| title_sort | fragmented sleep and the prevalence of hypertension in middle aged and older individuals |
| topic | blood pressure polysomnography fragmented sleep sleep heart health study cross-sectional study |
| url | https://www.dovepress.com/fragmented-sleep-and-the-prevalence-of-hypertension-in-middle-aged-and-peer-reviewed-fulltext-article-NSS |
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