Chronic kidney disease: the role of hyperuricemia and the possibility of urate-lowering therapy
Numerous epidemiological surveys may suggest that there is a relationship between chronic kidney disease (CKD) and asymptomatic hyperuricemia; at the same time there is growing evidence that elevated uric acid (UA) is the cause of kidney injury. The possible mechanisms of CKD in hyperuricemia are...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2018-04-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/810 |
| Summary: | Numerous epidemiological surveys may suggest that there is a relationship between chronic kidney disease (CKD) and asymptomatic hyperuricemia; at the same time there is growing evidence that elevated uric acid (UA) is the cause of kidney injury. The possible mechanisms of CKD in hyperuricemia are said to be immune inflammation that is both mediated by UA crystallization and independent from the latter; the impact on the activity of the renin- angiotensin-aldosterone system. The currently available optimistic data on the efficiency of drug correction of hyperuricemia at different stages of CKD are justified primarily by the long-term use of xanthine oxidase inhibitors (allopurinol, febuxostat) and allow urate- lowering therapy to be regarded as potentially nephroprotective. At the same time, further large-scale randomized controlled studies are needed to confirm this finding. |
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| ISSN: | 1996-7012 2310-158X |