Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
Type-I interferons (IFN-I) are cytokines essential for vertebrate antiviral defense, including against herpesviruses. IFN-I have potent direct antiviral activities and also mediate a multiplicity of immunoregulatory functions, which can either promote or dampen antiviral adaptive immune responses. P...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-10-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/1/3/383/ |
| _version_ | 1811318079691423744 |
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| author | Thomas Baranek Marc Dalod Nicolas Zucchini |
| author_facet | Thomas Baranek Marc Dalod Nicolas Zucchini |
| author_sort | Thomas Baranek |
| collection | DOAJ |
| description | Type-I interferons (IFN-I) are cytokines essential for vertebrate antiviral defense, including against herpesviruses. IFN-I have potent direct antiviral activities and also mediate a multiplicity of immunoregulatory functions, which can either promote or dampen antiviral adaptive immune responses. Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. There is strong evidence that pDCs could play a major role in the initial orchestration of both innate and adaptive antiviral immune responses. Depending on their activation pattern, pDC responses may be either protective or detrimental to the host. Here, we summarize and discuss current knowledge regarding pDC implication in the physiopathology of mouse and human herpesvirus infections, and we discuss how pDC functions could be manipulated in immunotherapeutic settings to promote health over disease. |
| first_indexed | 2024-04-13T12:19:30Z |
| format | Article |
| id | doaj.art-a1fdb80fab3a41d8bddb24e8be978136 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-13T12:19:30Z |
| publishDate | 2009-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a1fdb80fab3a41d8bddb24e8be9781362022-12-22T02:47:15ZengMDPI AGViruses1999-49152009-10-011338341910.3390/v1030383Plasmacytoid Dendritic Cells and the Control of Herpesvirus InfectionsThomas BaranekMarc DalodNicolas ZucchiniType-I interferons (IFN-I) are cytokines essential for vertebrate antiviral defense, including against herpesviruses. IFN-I have potent direct antiviral activities and also mediate a multiplicity of immunoregulatory functions, which can either promote or dampen antiviral adaptive immune responses. Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. There is strong evidence that pDCs could play a major role in the initial orchestration of both innate and adaptive antiviral immune responses. Depending on their activation pattern, pDC responses may be either protective or detrimental to the host. Here, we summarize and discuss current knowledge regarding pDC implication in the physiopathology of mouse and human herpesvirus infections, and we discuss how pDC functions could be manipulated in immunotherapeutic settings to promote health over disease.http://www.mdpi.com/1999-4915/1/3/383/plasmacytoid dendritic celltype-I interferonmouse cytomegalovirushuman cytomegalovirusherpesvirus type 1herpesvirus type 2immunotherapy |
| spellingShingle | Thomas Baranek Marc Dalod Nicolas Zucchini Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections Viruses plasmacytoid dendritic cell type-I interferon mouse cytomegalovirus human cytomegalovirus herpesvirus type 1 herpesvirus type 2 immunotherapy |
| title | Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections |
| title_full | Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections |
| title_fullStr | Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections |
| title_full_unstemmed | Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections |
| title_short | Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections |
| title_sort | plasmacytoid dendritic cells and the control of herpesvirus infections |
| topic | plasmacytoid dendritic cell type-I interferon mouse cytomegalovirus human cytomegalovirus herpesvirus type 1 herpesvirus type 2 immunotherapy |
| url | http://www.mdpi.com/1999-4915/1/3/383/ |
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