The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment
ContextWith the increasing number of older patients with acromegaly, it is important to understand the effects of aging on the quality of life (QoL) in acromegaly.ObjectiveTo investigate the factors associated with the QoL of older acromegaly patients.DesignThis was a single-center, retrospective, c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.819330/full |
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| author | Naoki Yamamoto Shin Urai Hidenori Fukuoka Masaaki Yamamoto Kenichi Yoshida Masaki Suzuki Hiroki Shichi Yasunori Fujita Keitaro Kanie Genzo Iguchi Genzo Iguchi Genzo Iguchi Yutaka Takahashi Yutaka Takahashi Wataru Ogawa |
| author_facet | Naoki Yamamoto Shin Urai Hidenori Fukuoka Masaaki Yamamoto Kenichi Yoshida Masaki Suzuki Hiroki Shichi Yasunori Fujita Keitaro Kanie Genzo Iguchi Genzo Iguchi Genzo Iguchi Yutaka Takahashi Yutaka Takahashi Wataru Ogawa |
| author_sort | Naoki Yamamoto |
| collection | DOAJ |
| description | ContextWith the increasing number of older patients with acromegaly, it is important to understand the effects of aging on the quality of life (QoL) in acromegaly.ObjectiveTo investigate the factors associated with the QoL of older acromegaly patients.DesignThis was a single-center, retrospective, cross-sectional study conducted between 2014 and 2019.MethodsAmong 90 acromegaly patients at Kobe University Hospital, 74 who had completed the QoL evaluation under treatment were enrolled (age = 62.0 [50.7–70.0], female 52%). SF-36 and the AcroQoL questionnaire were used to quantify QoL. The patients were divided into two groups: the young and middle-aged group, aged <65 years (51.0 [46.0–59.2], n =42), and the older group, aged ≥65 years (70.5 [69.0–73.0], n =32). The factors associated with the QoL scores were analyzed using univariate and multivariate regression analyses.ResultsThe scores for the physical component summary of SF-36 were negatively associated with age (P <0.01), while those for the mental or role/social component summary were positively associated (P <0.01, P =0.03, respectively). In contrast, AcroQoL scores were not associated with age. However, the different factors were associated with lower AcroQoL scores; arthropathy and higher BMI in the older group (P <0.01, and P =0.01, respectively), and treatment modalities and size of pituitary tumor in the young and middle-aged group (P <0.01, P =0.04, respectively). Replacement of hydrocortisone was commonly associated both in young and middle-aged group (P =0.04), and in older group (P =0.02).ConclusionWe showed that the factors associated with impaired QoL differed in the young and middle-aged, and older patients with acromegaly. In older patients, arthropathy and higher BMI were associated with poor QoL. These suggest the importance of early diagnosis and appropriate treatment in preventing arthropathy in acromegaly. |
| first_indexed | 2024-12-10T22:50:41Z |
| format | Article |
| id | doaj.art-a1fe217b88d946a9b8f31c2c59f6c91a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T22:50:41Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a1fe217b88d946a9b8f31c2c59f6c91a2022-12-22T01:30:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-02-011310.3389/fendo.2022.819330819330The Effect of Aging on Quality of Life in Acromegaly Patients Under TreatmentNaoki Yamamoto0Shin Urai1Hidenori Fukuoka2Masaaki Yamamoto3Kenichi Yoshida4Masaki Suzuki5Hiroki Shichi6Yasunori Fujita7Keitaro Kanie8Genzo Iguchi9Genzo Iguchi10Genzo Iguchi11Yutaka Takahashi12Yutaka Takahashi13Wataru Ogawa14Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Diabetes and Endocrinology, Kobe University Hospital, Kobe, JapanDivision of Diabetes and Endocrinology, Kobe University Hospital, Kobe, JapanDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanMedical Center for Student Health, Kobe University, Kobe, JapanDepartment of Biosignal Pathophysiology, Kobe University Graduate School of Medicine, Kobe, JapanDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Diabetes and Endocrinology, Nara Medical University, Kashihara, JapanDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, JapanContextWith the increasing number of older patients with acromegaly, it is important to understand the effects of aging on the quality of life (QoL) in acromegaly.ObjectiveTo investigate the factors associated with the QoL of older acromegaly patients.DesignThis was a single-center, retrospective, cross-sectional study conducted between 2014 and 2019.MethodsAmong 90 acromegaly patients at Kobe University Hospital, 74 who had completed the QoL evaluation under treatment were enrolled (age = 62.0 [50.7–70.0], female 52%). SF-36 and the AcroQoL questionnaire were used to quantify QoL. The patients were divided into two groups: the young and middle-aged group, aged <65 years (51.0 [46.0–59.2], n =42), and the older group, aged ≥65 years (70.5 [69.0–73.0], n =32). The factors associated with the QoL scores were analyzed using univariate and multivariate regression analyses.ResultsThe scores for the physical component summary of SF-36 were negatively associated with age (P <0.01), while those for the mental or role/social component summary were positively associated (P <0.01, P =0.03, respectively). In contrast, AcroQoL scores were not associated with age. However, the different factors were associated with lower AcroQoL scores; arthropathy and higher BMI in the older group (P <0.01, and P =0.01, respectively), and treatment modalities and size of pituitary tumor in the young and middle-aged group (P <0.01, P =0.04, respectively). Replacement of hydrocortisone was commonly associated both in young and middle-aged group (P =0.04), and in older group (P =0.02).ConclusionWe showed that the factors associated with impaired QoL differed in the young and middle-aged, and older patients with acromegaly. In older patients, arthropathy and higher BMI were associated with poor QoL. These suggest the importance of early diagnosis and appropriate treatment in preventing arthropathy in acromegaly.https://www.frontiersin.org/articles/10.3389/fendo.2022.819330/fullacromegalyquality of lifearthropathyolder patientsAcroQoL |
| spellingShingle | Naoki Yamamoto Shin Urai Hidenori Fukuoka Masaaki Yamamoto Kenichi Yoshida Masaki Suzuki Hiroki Shichi Yasunori Fujita Keitaro Kanie Genzo Iguchi Genzo Iguchi Genzo Iguchi Yutaka Takahashi Yutaka Takahashi Wataru Ogawa The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment Frontiers in Endocrinology acromegaly quality of life arthropathy older patients AcroQoL |
| title | The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment |
| title_full | The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment |
| title_fullStr | The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment |
| title_full_unstemmed | The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment |
| title_short | The Effect of Aging on Quality of Life in Acromegaly Patients Under Treatment |
| title_sort | effect of aging on quality of life in acromegaly patients under treatment |
| topic | acromegaly quality of life arthropathy older patients AcroQoL |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.819330/full |
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