An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) has become a prevalent malignancy, and its incidence and mortality rate are increasing worldwide. Accumulating evidence has indicated that lipid metabolism-related genes (LMRGs) are involved in the occurrence and development of HNSCC. This study investig...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2023/9708282 |
| _version_ | 1797903045852397568 |
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| author | Ling Qian Chenyu Zhou Keyi Wang Liuyang Li Wenhui Xia Yuan Fan |
| author_facet | Ling Qian Chenyu Zhou Keyi Wang Liuyang Li Wenhui Xia Yuan Fan |
| author_sort | Ling Qian |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) has become a prevalent malignancy, and its incidence and mortality rate are increasing worldwide. Accumulating evidence has indicated that lipid metabolism-related genes (LMRGs) are involved in the occurrence and development of HNSCC. This study investigated the latent association of lipid metabolism with HNSCC and established a prognostic signature based on LMRGs. A prognostic risk model composed of eight differentially expressed LMRGs (PHYH, CYP4F8, INMT, ELOVL6, PLPP3, BCHE, TPTE, and STAR) was constructed through The Cancer Genome Atlas database. Then, ELOVL6 expression was validated in oral squamous cell carcinoma (OSCC), which is a common type of HNSCC, by immunohistochemical analysis. ELOVL6 expression in the OSCC II/III group was significantly higher than that in the other three groups (normal, dysplasia, and OSCC I), and OSCC patients with high ELOVL6 expression had poorer survival than those with low ELOVL6 expression. In summary, the LMRG-based prognostic feature had prognostic predictive capacity. ELOVL6 may be a potential prognostic factor for HNSCC patients. |
| first_indexed | 2024-04-10T09:26:47Z |
| format | Article |
| id | doaj.art-a1fe3a9d5c77410cb5e7bf02ee508706 |
| institution | Directory Open Access Journal |
| issn | 2314-4378 |
| language | English |
| last_indexed | 2024-04-10T09:26:47Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj.art-a1fe3a9d5c77410cb5e7bf02ee5087062023-02-20T01:57:40ZengHindawi LimitedInternational Journal of Genomics2314-43782023-01-01202310.1155/2023/9708282An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell CarcinomaLing Qian0Chenyu Zhou1Keyi Wang2Liuyang Li3Wenhui Xia4Yuan Fan5Department of Oral Mucosal DiseasesDepartment of Oral Mucosal DiseasesDepartment of Oral Mucosal DiseasesDepartment of Oral Mucosal DiseasesDepartment of Oral Mucosal DiseasesDepartment of Oral Mucosal DiseasesHead and neck squamous cell carcinoma (HNSCC) has become a prevalent malignancy, and its incidence and mortality rate are increasing worldwide. Accumulating evidence has indicated that lipid metabolism-related genes (LMRGs) are involved in the occurrence and development of HNSCC. This study investigated the latent association of lipid metabolism with HNSCC and established a prognostic signature based on LMRGs. A prognostic risk model composed of eight differentially expressed LMRGs (PHYH, CYP4F8, INMT, ELOVL6, PLPP3, BCHE, TPTE, and STAR) was constructed through The Cancer Genome Atlas database. Then, ELOVL6 expression was validated in oral squamous cell carcinoma (OSCC), which is a common type of HNSCC, by immunohistochemical analysis. ELOVL6 expression in the OSCC II/III group was significantly higher than that in the other three groups (normal, dysplasia, and OSCC I), and OSCC patients with high ELOVL6 expression had poorer survival than those with low ELOVL6 expression. In summary, the LMRG-based prognostic feature had prognostic predictive capacity. ELOVL6 may be a potential prognostic factor for HNSCC patients.http://dx.doi.org/10.1155/2023/9708282 |
| spellingShingle | Ling Qian Chenyu Zhou Keyi Wang Liuyang Li Wenhui Xia Yuan Fan An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell Carcinoma International Journal of Genomics |
| title | An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell Carcinoma |
| title_full | An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell Carcinoma |
| title_fullStr | An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell Carcinoma |
| title_short | An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell Carcinoma |
| title_sort | investigation of the prognostic role of genes related to lipid metabolism in head and neck squamous cell carcinoma |
| url | http://dx.doi.org/10.1155/2023/9708282 |
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