First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil
Introduction: Fungal infections of the central nervous system present a variety of clinical syndromes, such as meningitis, encephalitis, raised intracranial pressure with a nonspecific presentation, and, in the last two decades, have increased the incidence of these fungal infections. Fungal meningo...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222005987 |
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| author | Rômulo Vieira Mello de Oliveira Danielly Corrêa-Moreira Túlio Vieira Mendes Gisela Lara da Costa Renata de Magalhães Vieira Cynthia Miranda Nascimento Buchele Rodrigo Schrage Lins Ana Beatriz Teixeira Brandão Camello Ferreira Daniela Barbosa Veira Rafael Santos de Aragão Pedroso Vinícius Tadeu Dias Pereira de Faria Manoel Marques Evangelista Oliveira |
| author_facet | Rômulo Vieira Mello de Oliveira Danielly Corrêa-Moreira Túlio Vieira Mendes Gisela Lara da Costa Renata de Magalhães Vieira Cynthia Miranda Nascimento Buchele Rodrigo Schrage Lins Ana Beatriz Teixeira Brandão Camello Ferreira Daniela Barbosa Veira Rafael Santos de Aragão Pedroso Vinícius Tadeu Dias Pereira de Faria Manoel Marques Evangelista Oliveira |
| author_sort | Rômulo Vieira Mello de Oliveira |
| collection | DOAJ |
| description | Introduction: Fungal infections of the central nervous system present a variety of clinical syndromes, such as meningitis, encephalitis, raised intracranial pressure with a nonspecific presentation, and, in the last two decades, have increased the incidence of these fungal infections. Fungal meningoencephalitis is frequently associated with Cryptococcus, but this report stands out for presenting one species of Penicillium genus. Objectives: Here, we present the first case of meningoencephalitis associated with brain injury caused by Penicillium chrysogenum, in a patient who is immunocompetent and was admitted to Hospital Naval Marcílio Dias, Rio de Janeiro, Brazil. Methods: To identify the fungal species, we performed phenotypic and genotypic methodologies, from the culture to the sequencing of internal transcribed spacer region, and β-tubulin gene, a rare fungus in cerebrospinal fluid cultures, belonging to the genus Penicillium, was identified. Conclusion: We highlight the importance of the first report of meningoencephalitis caused by P. chrysogenum in a patient who is immunocompetent, registered in Brazil. We also emphasize the need for further studies to determine an effective treatment with the least possible side effects for patients infected by fungi that are rarely related to the most severe forms of invasive infections. |
| first_indexed | 2024-04-11T05:12:04Z |
| format | Article |
| id | doaj.art-a1ff64b15a6b4c489229db969e7729c7 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-11T05:12:04Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-a1ff64b15a6b4c489229db969e7729c72022-12-25T04:16:43ZengElsevierInternational Journal of Infectious Diseases1201-97122023-01-011269497First report of fungal meningoencephalitis by Penicillium chrysogenum in BrazilRômulo Vieira Mello de Oliveira0Danielly Corrêa-Moreira1Túlio Vieira Mendes2Gisela Lara da Costa3Renata de Magalhães Vieira4Cynthia Miranda Nascimento Buchele5Rodrigo Schrage Lins6Ana Beatriz Teixeira Brandão Camello Ferreira7Daniela Barbosa Veira8Rafael Santos de Aragão Pedroso9Vinícius Tadeu Dias Pereira de Faria10Manoel Marques Evangelista Oliveira11Infectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, BrazilEvandro Chagas National Institute of Infectious Diseases, Rio de Janeiro, Brazil; Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, BrazilInfectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, Brazil; Evandro Chagas National Institute of Infectious Diseases, Rio de Janeiro, BrazilLaboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, BrazilInfectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, BrazilInfectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, BrazilInfectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, BrazilInfectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, BrazilInfectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, BrazilInfectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, BrazilInfectious Diseases Department, Marcilio Dias Naval Hospital, Rio de Janeiro, BrazilLaboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, Brazil; Corresponding author: Manoel Marques Evangelista OliveiraIntroduction: Fungal infections of the central nervous system present a variety of clinical syndromes, such as meningitis, encephalitis, raised intracranial pressure with a nonspecific presentation, and, in the last two decades, have increased the incidence of these fungal infections. Fungal meningoencephalitis is frequently associated with Cryptococcus, but this report stands out for presenting one species of Penicillium genus. Objectives: Here, we present the first case of meningoencephalitis associated with brain injury caused by Penicillium chrysogenum, in a patient who is immunocompetent and was admitted to Hospital Naval Marcílio Dias, Rio de Janeiro, Brazil. Methods: To identify the fungal species, we performed phenotypic and genotypic methodologies, from the culture to the sequencing of internal transcribed spacer region, and β-tubulin gene, a rare fungus in cerebrospinal fluid cultures, belonging to the genus Penicillium, was identified. Conclusion: We highlight the importance of the first report of meningoencephalitis caused by P. chrysogenum in a patient who is immunocompetent, registered in Brazil. We also emphasize the need for further studies to determine an effective treatment with the least possible side effects for patients infected by fungi that are rarely related to the most severe forms of invasive infections.http://www.sciencedirect.com/science/article/pii/S1201971222005987Fungal infectionsMeningoencephalitisPenicilliumPenicillium chrysogenumImmunocompetent patient |
| spellingShingle | Rômulo Vieira Mello de Oliveira Danielly Corrêa-Moreira Túlio Vieira Mendes Gisela Lara da Costa Renata de Magalhães Vieira Cynthia Miranda Nascimento Buchele Rodrigo Schrage Lins Ana Beatriz Teixeira Brandão Camello Ferreira Daniela Barbosa Veira Rafael Santos de Aragão Pedroso Vinícius Tadeu Dias Pereira de Faria Manoel Marques Evangelista Oliveira First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil International Journal of Infectious Diseases Fungal infections Meningoencephalitis Penicillium Penicillium chrysogenum Immunocompetent patient |
| title | First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil |
| title_full | First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil |
| title_fullStr | First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil |
| title_full_unstemmed | First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil |
| title_short | First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil |
| title_sort | first report of fungal meningoencephalitis by penicillium chrysogenum in brazil |
| topic | Fungal infections Meningoencephalitis Penicillium Penicillium chrysogenum Immunocompetent patient |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222005987 |
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