Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum
The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2015-07-01
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| Series: | Biology Open |
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| Online Access: | http://bio.biologists.org/content/4/7/865 |
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| author | Parthiv Haldipur Iswariya Sivaprakasam Vinod Periasamy Subashika Govindan Shyamala Mani |
| author_facet | Parthiv Haldipur Iswariya Sivaprakasam Vinod Periasamy Subashika Govindan Shyamala Mani |
| author_sort | Parthiv Haldipur |
| collection | DOAJ |
| description | The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of β-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of β-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of β-Catenin was shown to occur towards the source of a localized extracellular cue. |
| first_indexed | 2024-12-17T07:43:20Z |
| format | Article |
| id | doaj.art-a201c8bb2e10438884e2e598e61795ea |
| institution | Directory Open Access Journal |
| issn | 2046-6390 |
| language | English |
| last_indexed | 2024-12-17T07:43:20Z |
| publishDate | 2015-07-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Biology Open |
| spelling | doaj.art-a201c8bb2e10438884e2e598e61795ea2022-12-21T21:58:05ZengThe Company of BiologistsBiology Open2046-63902015-07-014786587210.1242/bio.009886009886Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellumParthiv Haldipur0Iswariya Sivaprakasam1Vinod Periasamy2Subashika Govindan3Shyamala Mani4 National Brain Research Centre, Manesar, Gurgaon 122050, Haryana, India Centre for Neuroscience, Indian Institute of Science, Bangalore 560012, Karnataka, India National Brain Research Centre, Manesar, Gurgaon 122050, Haryana, India Centre for Neuroscience, Indian Institute of Science, Bangalore 560012, Karnataka, India Centre for Neuroscience, Indian Institute of Science, Bangalore 560012, Karnataka, India The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of β-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of β-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of β-Catenin was shown to occur towards the source of a localized extracellular cue.http://bio.biologists.org/content/4/7/865CerebellumCell divisionβ-CateninSonic hedgehog |
| spellingShingle | Parthiv Haldipur Iswariya Sivaprakasam Vinod Periasamy Subashika Govindan Shyamala Mani Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum Biology Open Cerebellum Cell division β-Catenin Sonic hedgehog |
| title | Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum |
| title_full | Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum |
| title_fullStr | Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum |
| title_full_unstemmed | Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum |
| title_short | Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum |
| title_sort | asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum |
| topic | Cerebellum Cell division β-Catenin Sonic hedgehog |
| url | http://bio.biologists.org/content/4/7/865 |
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