Magnetic resonance imaging of the liver and spleen in the diagnosis of storage diseases
Storage diseases (thesaurismoses, storage reticuloses) are the common name of a large group of hyperplastic non-leukemic diseases characterized by congenital or acquired metabolic disturbances and abnormal accumulation of metabolic products in blood and/or cells of different organs and by hyperplasi...
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| Format: | Article |
| Language: | English |
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Luchevaya Diagnostika, LLC
2016-03-01
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| Series: | Вестник рентгенологии и радиологии |
| Subjects: | |
| Online Access: | https://www.russianradiology.ru/jour/article/view/78 |
| _version_ | 1797341705595256832 |
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| author | Z. M. Shapieva O. V. Kucheruk V. E. Sinitsyn E. A. Mershina |
| author_facet | Z. M. Shapieva O. V. Kucheruk V. E. Sinitsyn E. A. Mershina |
| author_sort | Z. M. Shapieva |
| collection | DOAJ |
| description | Storage diseases (thesaurismoses, storage reticuloses) are the common name of a large group of hyperplastic non-leukemic diseases characterized by congenital or acquired metabolic disturbances and abnormal accumulation of metabolic products in blood and/or cells of different organs and by hyperplasia of mononuclear phagocyte elements in the liver, spleen, bone marrow, lymph nodes, and other organs, which makes the diseases systemic. Among the imaging techniques for diffuse liver diseases, ultrasonography and X-ray computed tomography are most commonly used for their diagnosis and follow-up. Magnetic resonance imaging (MRI) has the highest sensitivity and specificity in diagnosing liver diseases. The paper considers the current MRI procedures that are used to diagnose storage diseases and to quantify found changes. For Gaucher’s disease, the potentials of novel techniques, such as MR spectroscopy, diffusion-weighted imaging (DWI), and chemical shift imaging (Dickson’s method) for the estimation of revealed changes, are described. For hemochromatosis, the contribution of T2 WI to the quantification of iron overload in the liver parenchyma is depicted, which is an alternative invasive procedure in its determination. Incorporation of MRI into the examination algorithm for patients with storagediseases will be able to improve the detection of these rare diseases and to monitorthe efficiency of performed therapy. |
| first_indexed | 2024-03-08T10:22:54Z |
| format | Article |
| id | doaj.art-a201d10931dc4d20b173f8b3c4c5d165 |
| institution | Directory Open Access Journal |
| issn | 0042-4676 2619-0478 |
| language | English |
| last_indexed | 2024-03-08T10:22:54Z |
| publishDate | 2016-03-01 |
| publisher | Luchevaya Diagnostika, LLC |
| record_format | Article |
| series | Вестник рентгенологии и радиологии |
| spelling | doaj.art-a201d10931dc4d20b173f8b3c4c5d1652024-01-27T18:38:33ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782016-03-0104546110.20862/0042-4676-2015-0-4-22-3178Magnetic resonance imaging of the liver and spleen in the diagnosis of storage diseasesZ. M. Shapieva0O. V. Kucheruk1V. E. Sinitsyn2E. A. Mershina3Republican Diagnostic CenterFederal Center of Treatment and Rehabilitation, Ministry of Health of the RFFederal Center of Treatment and Rehabilitation, Ministry of Health of the RF, Russian Medical Academy of Postgraduate Education, Ministry of Health of the RFFederal Center of Treatment and Rehabilitation, Ministry of Health of the RF, Russian Medical Academy of Postgraduate Education, Ministry of Health of the RFStorage diseases (thesaurismoses, storage reticuloses) are the common name of a large group of hyperplastic non-leukemic diseases characterized by congenital or acquired metabolic disturbances and abnormal accumulation of metabolic products in blood and/or cells of different organs and by hyperplasia of mononuclear phagocyte elements in the liver, spleen, bone marrow, lymph nodes, and other organs, which makes the diseases systemic. Among the imaging techniques for diffuse liver diseases, ultrasonography and X-ray computed tomography are most commonly used for their diagnosis and follow-up. Magnetic resonance imaging (MRI) has the highest sensitivity and specificity in diagnosing liver diseases. The paper considers the current MRI procedures that are used to diagnose storage diseases and to quantify found changes. For Gaucher’s disease, the potentials of novel techniques, such as MR spectroscopy, diffusion-weighted imaging (DWI), and chemical shift imaging (Dickson’s method) for the estimation of revealed changes, are described. For hemochromatosis, the contribution of T2 WI to the quantification of iron overload in the liver parenchyma is depicted, which is an alternative invasive procedure in its determination. Incorporation of MRI into the examination algorithm for patients with storagediseases will be able to improve the detection of these rare diseases and to monitorthe efficiency of performed therapy.https://www.russianradiology.ru/jour/article/view/78gaucher’s diseasehemochromatosismagnetic resonance imagingt2-weighted imagingdiffusion-weighted imaging |
| spellingShingle | Z. M. Shapieva O. V. Kucheruk V. E. Sinitsyn E. A. Mershina Magnetic resonance imaging of the liver and spleen in the diagnosis of storage diseases Вестник рентгенологии и радиологии gaucher’s disease hemochromatosis magnetic resonance imaging t2-weighted imaging diffusion-weighted imaging |
| title | Magnetic resonance imaging of the liver and spleen in the diagnosis of storage diseases |
| title_full | Magnetic resonance imaging of the liver and spleen in the diagnosis of storage diseases |
| title_fullStr | Magnetic resonance imaging of the liver and spleen in the diagnosis of storage diseases |
| title_full_unstemmed | Magnetic resonance imaging of the liver and spleen in the diagnosis of storage diseases |
| title_short | Magnetic resonance imaging of the liver and spleen in the diagnosis of storage diseases |
| title_sort | magnetic resonance imaging of the liver and spleen in the diagnosis of storage diseases |
| topic | gaucher’s disease hemochromatosis magnetic resonance imaging t2-weighted imaging diffusion-weighted imaging |
| url | https://www.russianradiology.ru/jour/article/view/78 |
| work_keys_str_mv | AT zmshapieva magneticresonanceimagingoftheliverandspleeninthediagnosisofstoragediseases AT ovkucheruk magneticresonanceimagingoftheliverandspleeninthediagnosisofstoragediseases AT vesinitsyn magneticresonanceimagingoftheliverandspleeninthediagnosisofstoragediseases AT eamershina magneticresonanceimagingoftheliverandspleeninthediagnosisofstoragediseases |