Multicentric Castleman's disease: Report of three cases

Castleman's disease is an uncommon benign B-cell lymphoproliferative disorder. According to lymph nodes distribution, there are two distinct subtypes of disease: unicentric and multicentric. Unicentric Castleman's disease is more common, localized to one site, and locally treated. On the c...

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Main Authors: M. Guazzaroni, MD PhD, F. Bocchinfuso, MD, E. Vasili, MD, A. Lacchè, MD, T. Ranalli, MD, A. Garipoli, MD, F. Di Tosto, MD, R. Floris, MD PhD
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Radiology Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043317304879
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author M. Guazzaroni, MD PhD
F. Bocchinfuso, MD
E. Vasili, MD
A. Lacchè, MD
T. Ranalli, MD
A. Garipoli, MD
F. Di Tosto, MD
R. Floris, MD PhD
author_facet M. Guazzaroni, MD PhD
F. Bocchinfuso, MD
E. Vasili, MD
A. Lacchè, MD
T. Ranalli, MD
A. Garipoli, MD
F. Di Tosto, MD
R. Floris, MD PhD
author_sort M. Guazzaroni, MD PhD
collection DOAJ
description Castleman's disease is an uncommon benign B-cell lymphoproliferative disorder. According to lymph nodes distribution, there are two distinct subtypes of disease: unicentric and multicentric. Unicentric Castleman's disease is more common, localized to one site, and locally treated. On the contrary, multicentric form is a rare systemic disease characterized by diffuse lymphadenopathy and inflammatory symptoms. We report three cases of persons that were initially suspected to have a lymphoma but were later histologically confirmed to have Multicentric Castleman's Disease. In addition, our work aims to investigate the role of fluorodeoxyglucose (FDG) PET/CT in evaluation of this rare condition. Keywords: Multicentric Castleman's disease, Hyaline vascular type, FDG PET/CT
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spelling doaj.art-a2021371d41b4e77ab655901994278df2022-12-22T00:46:42ZengElsevierRadiology Case Reports1930-04332019-03-01143328332Multicentric Castleman's disease: Report of three casesM. Guazzaroni, MD PhD0F. Bocchinfuso, MD1E. Vasili, MD2A. Lacchè, MD3T. Ranalli, MD4A. Garipoli, MD5F. Di Tosto, MD6R. Floris, MD PhD7Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata,” viale Oxford 81, Rome 00133, ItalyCastleman's disease is an uncommon benign B-cell lymphoproliferative disorder. According to lymph nodes distribution, there are two distinct subtypes of disease: unicentric and multicentric. Unicentric Castleman's disease is more common, localized to one site, and locally treated. On the contrary, multicentric form is a rare systemic disease characterized by diffuse lymphadenopathy and inflammatory symptoms. We report three cases of persons that were initially suspected to have a lymphoma but were later histologically confirmed to have Multicentric Castleman's Disease. In addition, our work aims to investigate the role of fluorodeoxyglucose (FDG) PET/CT in evaluation of this rare condition. Keywords: Multicentric Castleman's disease, Hyaline vascular type, FDG PET/CThttp://www.sciencedirect.com/science/article/pii/S1930043317304879
spellingShingle M. Guazzaroni, MD PhD
F. Bocchinfuso, MD
E. Vasili, MD
A. Lacchè, MD
T. Ranalli, MD
A. Garipoli, MD
F. Di Tosto, MD
R. Floris, MD PhD
Multicentric Castleman's disease: Report of three cases
Radiology Case Reports
title Multicentric Castleman's disease: Report of three cases
title_full Multicentric Castleman's disease: Report of three cases
title_fullStr Multicentric Castleman's disease: Report of three cases
title_full_unstemmed Multicentric Castleman's disease: Report of three cases
title_short Multicentric Castleman's disease: Report of three cases
title_sort multicentric castleman s disease report of three cases
url http://www.sciencedirect.com/science/article/pii/S1930043317304879
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