Clinical characteristics and outcomes of pediatric germ cell tumors in Ali-Asghar Children’s Hospital; 1990-2004
Background: Germ cell tumor (GCT) account for approximately 2-3% of all malignancies in childhood. About 20% of patients with GCT are still resistant to therapy. Methods: This study was undertaken on 57 patients with Germ cell tumor who were admitted to Ali Asghar Children’s Hospital during 1990-200...
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Tehran University of Medical Sciences
2007-05-01
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| Series: | Tehran University Medical Journal |
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| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3263.pdf&manuscript_id=3263 |
| _version_ | 1818519273801252864 |
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| author | Ansari Sh Vossogh P Tabarok A |
| author_facet | Ansari Sh Vossogh P Tabarok A |
| author_sort | Ansari Sh |
| collection | DOAJ |
| description | Background: Germ cell tumor (GCT) account for approximately 2-3% of all malignancies in childhood. About 20% of patients with GCT are still resistant to therapy. Methods: This study was undertaken on 57 patients with Germ cell tumor who were admitted to Ali Asghar Children’s Hospital during 1990-2004. Through this study, information about sex, age type of pathology, clinical sign, treatment and survival (5-year period) was gathered in order to have better treatment and follow up. This study was carried out as across-sectional survey and the obtained data was analyzed via Spss 10 soft ware. Results: The findings showed that the mean age of patients was 4/9 ± 0/1 (1mo -14y), male 54%, female 46%, male/female, ratio=1/1. Site of tumor: saccrococcygeal 57/8 %( 33), gonadal 42% (24). Pathological type is yolk sac 61/4% (35), dysgerminoma 12/2% (7), malignant teratoma 14% (8), embryonal carcinoma 10/5% (6). The most common clinical sign were buttock mass 31/5% (18), abdominal pain 10/5% (6), abdominal mass 17/5%(10), testicular mass 28% (16). All of the patients were treated with chemotherapy (bleomycine, vinblastin, cisplatinum) mean of duration follow up were 48/4 months. In all of patients 31/5% (18) of the cases were alive and 70% (40) of patients were relapse and 15/7% (9) no information, 52/6% (30) of cases were expired. Five years survival of patients was 62%. Conclusion: The analysis of the patients treated shows that extragonadal location of primary tumor (specially sacrococcygeal), level of AFP above 10 ng/ml in patients ,6 or more months of age and metastatic disease were the most unfavorable factors for overall survival. |
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| format | Article |
| id | doaj.art-a2030c8d4def4d6a90ed0d2127528219 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-11T01:21:54Z |
| publishDate | 2007-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-a2030c8d4def4d6a90ed0d21275282192022-12-22T01:25:41ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222007-05-0164116568Clinical characteristics and outcomes of pediatric germ cell tumors in Ali-Asghar Children’s Hospital; 1990-2004Ansari ShVossogh PTabarok ABackground: Germ cell tumor (GCT) account for approximately 2-3% of all malignancies in childhood. About 20% of patients with GCT are still resistant to therapy. Methods: This study was undertaken on 57 patients with Germ cell tumor who were admitted to Ali Asghar Children’s Hospital during 1990-2004. Through this study, information about sex, age type of pathology, clinical sign, treatment and survival (5-year period) was gathered in order to have better treatment and follow up. This study was carried out as across-sectional survey and the obtained data was analyzed via Spss 10 soft ware. Results: The findings showed that the mean age of patients was 4/9 ± 0/1 (1mo -14y), male 54%, female 46%, male/female, ratio=1/1. Site of tumor: saccrococcygeal 57/8 %( 33), gonadal 42% (24). Pathological type is yolk sac 61/4% (35), dysgerminoma 12/2% (7), malignant teratoma 14% (8), embryonal carcinoma 10/5% (6). The most common clinical sign were buttock mass 31/5% (18), abdominal pain 10/5% (6), abdominal mass 17/5%(10), testicular mass 28% (16). All of the patients were treated with chemotherapy (bleomycine, vinblastin, cisplatinum) mean of duration follow up were 48/4 months. In all of patients 31/5% (18) of the cases were alive and 70% (40) of patients were relapse and 15/7% (9) no information, 52/6% (30) of cases were expired. Five years survival of patients was 62%. Conclusion: The analysis of the patients treated shows that extragonadal location of primary tumor (specially sacrococcygeal), level of AFP above 10 ng/ml in patients ,6 or more months of age and metastatic disease were the most unfavorable factors for overall survival.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3263.pdf&manuscript_id=3263Germ cell- teratomadysgerminomaalpha feto protein |
| spellingShingle | Ansari Sh Vossogh P Tabarok A Clinical characteristics and outcomes of pediatric germ cell tumors in Ali-Asghar Children’s Hospital; 1990-2004 Tehran University Medical Journal Germ cell- teratoma dysgerminoma alpha feto protein |
| title | Clinical characteristics and outcomes of pediatric germ cell tumors in Ali-Asghar Children’s Hospital; 1990-2004 |
| title_full | Clinical characteristics and outcomes of pediatric germ cell tumors in Ali-Asghar Children’s Hospital; 1990-2004 |
| title_fullStr | Clinical characteristics and outcomes of pediatric germ cell tumors in Ali-Asghar Children’s Hospital; 1990-2004 |
| title_full_unstemmed | Clinical characteristics and outcomes of pediatric germ cell tumors in Ali-Asghar Children’s Hospital; 1990-2004 |
| title_short | Clinical characteristics and outcomes of pediatric germ cell tumors in Ali-Asghar Children’s Hospital; 1990-2004 |
| title_sort | clinical characteristics and outcomes of pediatric germ cell tumors in ali asghar children s hospital 1990 2004 |
| topic | Germ cell- teratoma dysgerminoma alpha feto protein |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3263.pdf&manuscript_id=3263 |
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