Association of Carotid-Femoral Pulse Wave Velocity and Ejection Duration with Target Organ Damage
Background: Carotid-femoral pulse wave velocity (cfPWV) and ejection duration (ED) have different impacts on target organ damage (TOD). The aim of this study was to determine the relationship of cfPWV and ED with TOD. Methods: A total of 1254 patients (64.27% males) from Ruijin Hospital were enrolle...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-02-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/24/2/10.31083/j.rcm2402041 |
| _version_ | 1797893383971143680 |
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| author | Yaya Bai Huiying Jia Alberto Avolio Yi Qian Junli Zuo |
| author_facet | Yaya Bai Huiying Jia Alberto Avolio Yi Qian Junli Zuo |
| author_sort | Yaya Bai |
| collection | DOAJ |
| description | Background: Carotid-femoral pulse wave velocity (cfPWV) and ejection duration (ED) have different impacts on target organ damage (TOD). The aim of this study was to determine the relationship of cfPWV and ED with TOD. Methods: A total of 1254 patients (64.27% males) from Ruijin Hospital were enrolled in this study from December 2018 to August 2022. Medical records, blood samples and urine samples were collected. The cfPWV was measured and ED was generated using SphygmoCor software (version 8.0, AtCor Medical, Sydney, Australia). TOD including left ventricular hypertrophy (LVH), microalbuminuria, chronic kidney disease (CKD), and abnormality of carotid intima-media thickness (CIMT) were evaluated. Results: Multiple stepwise linear regression models of cfPWV and ED (individually or together) showed that cfPWV was positively correlated with left ventricular mass index (LVMI) (β= 0.131, p = 0.002) and Log (albumin-creatinine ratio, ACR) (β= 0.123, p = 0.004), while ED was negatively correlated with LVMI (β= –0.244, p < 0.001) and positively correlated with the estimated glomerular filtration rate (eGFR) (β= 0.115, p = 0.003). When cfPWV and ED were added separately or together in multiple stepwise logistic regression models, cfPWV was associated with CKD [odds ratio (OR) = 1.240, 95% confidence interval (CI) 1.055–1.458, p = 0.009], while ED was associated with LVH (OR = 0.983, 95% CI 0.975–0.992, p < 0.001). In the control group with normal cfPWV and normal ED, LVH was significantly lower in patients with high ED (OR = 0.574, 95% CI 0.374–0.882, p = 0.011), but significantly elevated in those with high cfPWV and low ED (OR = 6.799, 95% CI 1.305–35.427, p = 0.023). Conclusions: cfPWV was more strongly associated with renal damage, while ED was more strongly associated with cardiac dysfunction. cfPWV and ED affect each other, and together have an effect on LVH. |
| first_indexed | 2024-04-10T06:51:59Z |
| format | Article |
| id | doaj.art-a20421cf9d9c48ba84e130ed92a3e743 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-04-10T06:51:59Z |
| publishDate | 2023-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-a20421cf9d9c48ba84e130ed92a3e7432023-02-28T08:09:00ZengIMR PressReviews in Cardiovascular Medicine1530-65502023-02-012424110.31083/j.rcm2402041S1530-6550(22)00817-1Association of Carotid-Femoral Pulse Wave Velocity and Ejection Duration with Target Organ DamageYaya Bai0Huiying Jia1Alberto Avolio2Yi Qian3Junli Zuo4Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, ChinaDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, ChinaDepartment of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, 2109 Sydney, AustraliaDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, ChinaDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, ChinaBackground: Carotid-femoral pulse wave velocity (cfPWV) and ejection duration (ED) have different impacts on target organ damage (TOD). The aim of this study was to determine the relationship of cfPWV and ED with TOD. Methods: A total of 1254 patients (64.27% males) from Ruijin Hospital were enrolled in this study from December 2018 to August 2022. Medical records, blood samples and urine samples were collected. The cfPWV was measured and ED was generated using SphygmoCor software (version 8.0, AtCor Medical, Sydney, Australia). TOD including left ventricular hypertrophy (LVH), microalbuminuria, chronic kidney disease (CKD), and abnormality of carotid intima-media thickness (CIMT) were evaluated. Results: Multiple stepwise linear regression models of cfPWV and ED (individually or together) showed that cfPWV was positively correlated with left ventricular mass index (LVMI) (β= 0.131, p = 0.002) and Log (albumin-creatinine ratio, ACR) (β= 0.123, p = 0.004), while ED was negatively correlated with LVMI (β= –0.244, p < 0.001) and positively correlated with the estimated glomerular filtration rate (eGFR) (β= 0.115, p = 0.003). When cfPWV and ED were added separately or together in multiple stepwise logistic regression models, cfPWV was associated with CKD [odds ratio (OR) = 1.240, 95% confidence interval (CI) 1.055–1.458, p = 0.009], while ED was associated with LVH (OR = 0.983, 95% CI 0.975–0.992, p < 0.001). In the control group with normal cfPWV and normal ED, LVH was significantly lower in patients with high ED (OR = 0.574, 95% CI 0.374–0.882, p = 0.011), but significantly elevated in those with high cfPWV and low ED (OR = 6.799, 95% CI 1.305–35.427, p = 0.023). Conclusions: cfPWV was more strongly associated with renal damage, while ED was more strongly associated with cardiac dysfunction. cfPWV and ED affect each other, and together have an effect on LVH.https://www.imrpress.com/journal/RCM/24/2/10.31083/j.rcm2402041carotid-femoral pulse wave velocityejection durationtarget organ damagerenal damageleft ventricular hypertrophy |
| spellingShingle | Yaya Bai Huiying Jia Alberto Avolio Yi Qian Junli Zuo Association of Carotid-Femoral Pulse Wave Velocity and Ejection Duration with Target Organ Damage Reviews in Cardiovascular Medicine carotid-femoral pulse wave velocity ejection duration target organ damage renal damage left ventricular hypertrophy |
| title | Association of Carotid-Femoral Pulse Wave Velocity and Ejection Duration with Target Organ Damage |
| title_full | Association of Carotid-Femoral Pulse Wave Velocity and Ejection Duration with Target Organ Damage |
| title_fullStr | Association of Carotid-Femoral Pulse Wave Velocity and Ejection Duration with Target Organ Damage |
| title_full_unstemmed | Association of Carotid-Femoral Pulse Wave Velocity and Ejection Duration with Target Organ Damage |
| title_short | Association of Carotid-Femoral Pulse Wave Velocity and Ejection Duration with Target Organ Damage |
| title_sort | association of carotid femoral pulse wave velocity and ejection duration with target organ damage |
| topic | carotid-femoral pulse wave velocity ejection duration target organ damage renal damage left ventricular hypertrophy |
| url | https://www.imrpress.com/journal/RCM/24/2/10.31083/j.rcm2402041 |
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