Nanoparticle approaches for the renin-angiotensin system
The renin-angiotensin system (RAS) is a hormonal cascade that contributes to several disorders: systemic hypertension, heart failure, kidney disease, and neurodegenerative disease. Activation of the RAS can promote inflammation and fibrosis. Drugs that target the RAS can be classified into 3 categor...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023041580 |
| _version_ | 1797807192283283456 |
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| author | Sajini D. Hettiarachchi, PhD Young M. Kwon Yadollah Omidi Robert C. Speth |
| author_facet | Sajini D. Hettiarachchi, PhD Young M. Kwon Yadollah Omidi Robert C. Speth |
| author_sort | Sajini D. Hettiarachchi, PhD |
| collection | DOAJ |
| description | The renin-angiotensin system (RAS) is a hormonal cascade that contributes to several disorders: systemic hypertension, heart failure, kidney disease, and neurodegenerative disease. Activation of the RAS can promote inflammation and fibrosis. Drugs that target the RAS can be classified into 3 categories, AT1 angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, and renin inhibitors. The therapeutic efficacy of current RAS-inhibiting drugs is limited by poor penetration across the blood-brain barrier, low bioavailability, and to some extent, short half-lives. Nanoparticle-mediated drug delivery systems (DDSs) are possible emerging alternatives to overcome such limitations. Nanoparticles are ideally 1–100 nm in size and are considered efficient DDSs mainly due to their unique characteristics, including water dispersity, prolonged half-life in blood circulation, smaller size, and biocompatibility. Nano-scale DDSs can reduce the drug dosage frequency and acute toxicity of drugs while enhancing therapeutic success. Different types of nanoparticles, such as chitosan, polymeric, and nanofibers, have been examined in RAS-related studies, especially in hypertension, cardiovascular disease, and COVID-19. In this review article, we summarize the physical and chemical characteristics of each nanoparticle to elaborate on their potential use in RAS-related nano-drug delivery research and clinical application. |
| first_indexed | 2024-03-13T06:18:52Z |
| format | Article |
| id | doaj.art-a20459e656c546c08cec8ab0db5c2272 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T06:18:52Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-a20459e656c546c08cec8ab0db5c22722023-06-10T04:28:12ZengElsevierHeliyon2405-84402023-06-0196e16951Nanoparticle approaches for the renin-angiotensin systemSajini D. Hettiarachchi, PhD0Young M. Kwon1Yadollah Omidi2Robert C. Speth3Department of Pharmaceutical Sciences, Barry and Judy College of Pharmacy, Nova Southeastern University, 3200 S University Dr, Davie, FL, 33328 USA; Corresponding author.Department of Pharmaceutical Sciences, Barry and Judy College of Pharmacy, Nova Southeastern University, 3200 S University Dr, Davie, FL, 33328 USADepartment of Pharmaceutical Sciences, Barry and Judy College of Pharmacy, Nova Southeastern University, 3200 S University Dr, Davie, FL, 33328 USADepartment of Pharmaceutical Sciences, Barry and Judy College of Pharmacy, Nova Southeastern University, 3200 S University Dr, Davie, FL, 33328 USA; Department of Pharmacology and Physiology, School of Medicine Georgetown University, 3900 Reservoir Rd. NW, Washington, DC, 20057, USA; Corresponding author. Department of Pharmaseutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 S University Dr, Davie, FL, 33328 USA.The renin-angiotensin system (RAS) is a hormonal cascade that contributes to several disorders: systemic hypertension, heart failure, kidney disease, and neurodegenerative disease. Activation of the RAS can promote inflammation and fibrosis. Drugs that target the RAS can be classified into 3 categories, AT1 angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, and renin inhibitors. The therapeutic efficacy of current RAS-inhibiting drugs is limited by poor penetration across the blood-brain barrier, low bioavailability, and to some extent, short half-lives. Nanoparticle-mediated drug delivery systems (DDSs) are possible emerging alternatives to overcome such limitations. Nanoparticles are ideally 1–100 nm in size and are considered efficient DDSs mainly due to their unique characteristics, including water dispersity, prolonged half-life in blood circulation, smaller size, and biocompatibility. Nano-scale DDSs can reduce the drug dosage frequency and acute toxicity of drugs while enhancing therapeutic success. Different types of nanoparticles, such as chitosan, polymeric, and nanofibers, have been examined in RAS-related studies, especially in hypertension, cardiovascular disease, and COVID-19. In this review article, we summarize the physical and chemical characteristics of each nanoparticle to elaborate on their potential use in RAS-related nano-drug delivery research and clinical application.http://www.sciencedirect.com/science/article/pii/S2405844023041580Renin-angiotensin systemNanoparticlesDrug deliveryHypertensionCardiovascular diseaseCOVID-19 |
| spellingShingle | Sajini D. Hettiarachchi, PhD Young M. Kwon Yadollah Omidi Robert C. Speth Nanoparticle approaches for the renin-angiotensin system Heliyon Renin-angiotensin system Nanoparticles Drug delivery Hypertension Cardiovascular disease COVID-19 |
| title | Nanoparticle approaches for the renin-angiotensin system |
| title_full | Nanoparticle approaches for the renin-angiotensin system |
| title_fullStr | Nanoparticle approaches for the renin-angiotensin system |
| title_full_unstemmed | Nanoparticle approaches for the renin-angiotensin system |
| title_short | Nanoparticle approaches for the renin-angiotensin system |
| title_sort | nanoparticle approaches for the renin angiotensin system |
| topic | Renin-angiotensin system Nanoparticles Drug delivery Hypertension Cardiovascular disease COVID-19 |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023041580 |
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