Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary Syndrome
<i>Background and Objectives:</i> Excessive coronary thrombus burden is known to cause an increase in mortality and major adverse cardiac events (MACEs) in NSTE-ACS (non-ST acute coronary syndrome) patients. We investigated the association between the systemic immune-inflammation index (...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/2/143 |
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| author | Uğur Özkan Muhammet Gürdoğan Cihan Öztürk Melik Demir Ömer Feridun Akkuş Efe Yılmaz Servet Altay |
| author_facet | Uğur Özkan Muhammet Gürdoğan Cihan Öztürk Melik Demir Ömer Feridun Akkuş Efe Yılmaz Servet Altay |
| author_sort | Uğur Özkan |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Excessive coronary thrombus burden is known to cause an increase in mortality and major adverse cardiac events (MACEs) in NSTE-ACS (non-ST acute coronary syndrome) patients. We investigated the association between the systemic immune-inflammation index (SII) and coronary thrombus burden in patients with non-ST segment elevation myocardial infarction (NSTEMI) who underwent coronary angiography and percutaneous coronary intervention (PCI). <i>Materials and Methods:</i> A total of 389 patients with the diagnosis of NSTEMI participated in our study. Coronary thrombus burden was classified in the TIMI (thrombolysis in myocardial infarction) thrombus grade scale and patients were divided into two groups: a TIMI thrombus grade 0–1 group (<i>n</i> = 209, 157 males) and a TIMI thrombus grade 2–6 group (<i>n</i> = 180, 118 males). Demographics, angiographic lesion images, coronary thrombus burden, clinical risk factors, laboratory parameters, and SII score were compared between the two groups. <i>Results:</i> The high thrombus burden patient group had a higher neutrophil count, WBC count, platelet count, and systemic immune-inflammation index (SII) (<i>p</i> < 0.001). The receiver operating characteristic (ROC) curve analysis showed that at a cutoff of 1103, the value of SII manifested 74.4% sensitivity and 74.6% specificity for detecting a high coronary thrombus burden. <i>Conclusions:</i> Our study showed that the SII levels at hospital admission were independently associated with high coronary thrombus with NSTEMI. |
| first_indexed | 2024-03-09T21:30:43Z |
| format | Article |
| id | doaj.art-a2064ca4d8b44b958eddfec75eea82d9 |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T21:30:43Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-a2064ca4d8b44b958eddfec75eea82d92023-11-23T20:58:39ZengMDPI AGMedicina1010-660X1648-91442022-01-0158214310.3390/medicina58020143Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary SyndromeUğur Özkan0Muhammet Gürdoğan1Cihan Öztürk2Melik Demir3Ömer Feridun Akkuş4Efe Yılmaz5Servet Altay6Department of Cardiology, School of Medicine, Trakya University, Edirne 22030, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, Edirne 22030, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, Edirne 22030, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, Edirne 22030, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, Edirne 22030, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, Edirne 22030, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, Edirne 22030, Turkey<i>Background and Objectives:</i> Excessive coronary thrombus burden is known to cause an increase in mortality and major adverse cardiac events (MACEs) in NSTE-ACS (non-ST acute coronary syndrome) patients. We investigated the association between the systemic immune-inflammation index (SII) and coronary thrombus burden in patients with non-ST segment elevation myocardial infarction (NSTEMI) who underwent coronary angiography and percutaneous coronary intervention (PCI). <i>Materials and Methods:</i> A total of 389 patients with the diagnosis of NSTEMI participated in our study. Coronary thrombus burden was classified in the TIMI (thrombolysis in myocardial infarction) thrombus grade scale and patients were divided into two groups: a TIMI thrombus grade 0–1 group (<i>n</i> = 209, 157 males) and a TIMI thrombus grade 2–6 group (<i>n</i> = 180, 118 males). Demographics, angiographic lesion images, coronary thrombus burden, clinical risk factors, laboratory parameters, and SII score were compared between the two groups. <i>Results:</i> The high thrombus burden patient group had a higher neutrophil count, WBC count, platelet count, and systemic immune-inflammation index (SII) (<i>p</i> < 0.001). The receiver operating characteristic (ROC) curve analysis showed that at a cutoff of 1103, the value of SII manifested 74.4% sensitivity and 74.6% specificity for detecting a high coronary thrombus burden. <i>Conclusions:</i> Our study showed that the SII levels at hospital admission were independently associated with high coronary thrombus with NSTEMI.https://www.mdpi.com/1648-9144/58/2/143systemic immune-inflammation indexcoronary thrombus burdennon-st acute coronary syn-dromeatherosclerosisplaque rupturethrombus formation |
| spellingShingle | Uğur Özkan Muhammet Gürdoğan Cihan Öztürk Melik Demir Ömer Feridun Akkuş Efe Yılmaz Servet Altay Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary Syndrome Medicina systemic immune-inflammation index coronary thrombus burden non-st acute coronary syn-drome atherosclerosis plaque rupture thrombus formation |
| title | Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary Syndrome |
| title_full | Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary Syndrome |
| title_fullStr | Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary Syndrome |
| title_full_unstemmed | Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary Syndrome |
| title_short | Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary Syndrome |
| title_sort | systemic immune inflammation index a novel predictor of coronary thrombus burden in patients with non st acute coronary syndrome |
| topic | systemic immune-inflammation index coronary thrombus burden non-st acute coronary syn-drome atherosclerosis plaque rupture thrombus formation |
| url | https://www.mdpi.com/1648-9144/58/2/143 |
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