Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway

Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway

Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis. However, it is not clear that whether p53-induced mitochondrial fission is critic...

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Bibliographic Details
Main Authors: Jia Qi, Feng Wang, Ping Yang, Xuelian Wang, Renjie Xu, Jihui Chen, Yanggang Yuan, Zhaoyang Lu, Junli Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
mitochondrial fission
cardiomyocyte apoptosis
Angiotensin II
hypertension
Drp1
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00176/full

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