R<sub>2</sub><sup>2</sup>(8) motifs in Aminopyrimidine sulfonate/carboxylate interactions: Crystal structures of pyrimethaminium benzenesulfonate monohydrate (2:2:1) and 2-amino-4,6-dimethylpyrimidinium sulfosalicylate dihydrate (4:2:2)

R<sub>2</sub><sup>2</sup>(8) motifs in Aminopyrimidine sulfonate/carboxylate interactions: Crystal structures of pyrimethaminium benzenesulfonate monohydrate (2:2:1) and 2-amino-4,6-dimethylpyrimidinium sulfosalicylate dihydrate (4:2:2)

<p>Abstract</p> <p>Background</p> <p>Pyrimethamine [2,4-diamino-5-(<it>p</it>-chlorophenyl)-6-ethylpyrimidine] is an antifolate drug used in anti-malarial chemotherapy. Pyrimidine and aminopyrimidine derivatives are biologically important compounds owing to...

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Bibliographic Details
Main Authors: Muthiah Packianathan, Balasubramani Kasthuri, Lynch Daniel E
Format: Article
Language:English
Published: BMC 2007-11-01
Series:Chemistry Central Journal
Online Access:http://journal.chemistrycentral.com/content/1/1/28

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