Emerging Roles of p53 Family Members in Glucose Metabolism
Glucose is the key source for most organisms to provide energy, as well as the key source for metabolites to generate building blocks in cells. The deregulation of glucose homeostasis occurs in various diseases, including the enhanced aerobic glycolysis that is observed in cancers, and insulin resis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/19/3/776 |
| _version_ | 1811233019185332224 |
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| author | Yoko Itahana Koji Itahana |
| author_facet | Yoko Itahana Koji Itahana |
| author_sort | Yoko Itahana |
| collection | DOAJ |
| description | Glucose is the key source for most organisms to provide energy, as well as the key source for metabolites to generate building blocks in cells. The deregulation of glucose homeostasis occurs in various diseases, including the enhanced aerobic glycolysis that is observed in cancers, and insulin resistance in diabetes. Although p53 is thought to suppress tumorigenesis primarily by inducing cell cycle arrest, apoptosis, and senescence in response to stress, the non-canonical functions of p53 in cellular energy homeostasis and metabolism are also emerging as critical factors for tumor suppression. Increasing evidence suggests that p53 plays a significant role in regulating glucose homeostasis. Furthermore, the p53 family members p63 and p73, as well as gain-of-function p53 mutants, are also involved in glucose metabolism. Indeed, how this protein family regulates cellular energy levels is complicated and difficult to disentangle. This review discusses the roles of the p53 family in multiple metabolic processes, such as glycolysis, gluconeogenesis, aerobic respiration, and autophagy. We also discuss how the dysregulation of the p53 family in these processes leads to diseases such as cancer and diabetes. Elucidating the complexities of the p53 family members in glucose homeostasis will improve our understanding of these diseases. |
| first_indexed | 2024-04-12T11:13:47Z |
| format | Article |
| id | doaj.art-a207e0d0d41549509b3dd9e26ce19561 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T11:13:47Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a207e0d0d41549509b3dd9e26ce195612022-12-22T03:35:33ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-03-0119377610.3390/ijms19030776ijms19030776Emerging Roles of p53 Family Members in Glucose MetabolismYoko Itahana0Koji Itahana1Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, SingaporeCancer and Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, SingaporeGlucose is the key source for most organisms to provide energy, as well as the key source for metabolites to generate building blocks in cells. The deregulation of glucose homeostasis occurs in various diseases, including the enhanced aerobic glycolysis that is observed in cancers, and insulin resistance in diabetes. Although p53 is thought to suppress tumorigenesis primarily by inducing cell cycle arrest, apoptosis, and senescence in response to stress, the non-canonical functions of p53 in cellular energy homeostasis and metabolism are also emerging as critical factors for tumor suppression. Increasing evidence suggests that p53 plays a significant role in regulating glucose homeostasis. Furthermore, the p53 family members p63 and p73, as well as gain-of-function p53 mutants, are also involved in glucose metabolism. Indeed, how this protein family regulates cellular energy levels is complicated and difficult to disentangle. This review discusses the roles of the p53 family in multiple metabolic processes, such as glycolysis, gluconeogenesis, aerobic respiration, and autophagy. We also discuss how the dysregulation of the p53 family in these processes leads to diseases such as cancer and diabetes. Elucidating the complexities of the p53 family members in glucose homeostasis will improve our understanding of these diseases.http://www.mdpi.com/1422-0067/19/3/776p53p63p73p53 mutantglucose metabolismglycolysismitochondriaautophagydiabetescancer |
| spellingShingle | Yoko Itahana Koji Itahana Emerging Roles of p53 Family Members in Glucose Metabolism International Journal of Molecular Sciences p53 p63 p73 p53 mutant glucose metabolism glycolysis mitochondria autophagy diabetes cancer |
| title | Emerging Roles of p53 Family Members in Glucose Metabolism |
| title_full | Emerging Roles of p53 Family Members in Glucose Metabolism |
| title_fullStr | Emerging Roles of p53 Family Members in Glucose Metabolism |
| title_full_unstemmed | Emerging Roles of p53 Family Members in Glucose Metabolism |
| title_short | Emerging Roles of p53 Family Members in Glucose Metabolism |
| title_sort | emerging roles of p53 family members in glucose metabolism |
| topic | p53 p63 p73 p53 mutant glucose metabolism glycolysis mitochondria autophagy diabetes cancer |
| url | http://www.mdpi.com/1422-0067/19/3/776 |
| work_keys_str_mv | AT yokoitahana emergingrolesofp53familymembersinglucosemetabolism AT kojiitahana emergingrolesofp53familymembersinglucosemetabolism |