Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances
Non-enantioselective alcohol dehydrogenases (ADHs) are rarely found in the biocatalysis portfolio. Generally, highly enantioselective ADHs are sought for. Using such ADHs for the oxidation of racemic alcohols generally results in a kinetic resolution of the starting material, which is unfavourable i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Catalysis |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fctls.2022.926316/full |
| _version_ | 1811238013218324480 |
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| author | Eva Puchľová Thomas Hilberath Kvetoslava Vranková Frank Hollmann |
| author_facet | Eva Puchľová Thomas Hilberath Kvetoslava Vranková Frank Hollmann |
| author_sort | Eva Puchľová |
| collection | DOAJ |
| description | Non-enantioselective alcohol dehydrogenases (ADHs) are rarely found in the biocatalysis portfolio. Generally, highly enantioselective ADHs are sought for. Using such ADHs for the oxidation of racemic alcohols generally results in a kinetic resolution of the starting material, which is unfavourable if the ketone represents the product of interest. In the current contribution we report the ADH from Sphingobium yanoikuyae (SyADH) as non-enantioselective ADH for the complete oxidation or rac-heptan-2-ol (representing further 2-alkanols). |
| first_indexed | 2024-04-12T12:34:27Z |
| format | Article |
| id | doaj.art-a2085280318248d7b9bc4c434167826e |
| institution | Directory Open Access Journal |
| issn | 2673-7841 |
| language | English |
| last_indexed | 2024-04-12T12:34:27Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Catalysis |
| spelling | doaj.art-a2085280318248d7b9bc4c434167826e2022-12-22T03:32:56ZengFrontiers Media S.A.Frontiers in Catalysis2673-78412022-06-01210.3389/fctls.2022.926316926316Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and FragrancesEva Puchľová0Thomas Hilberath1Kvetoslava Vranková2Frank Hollmann3Axxence Slovakia s.r.o, Bratislava, SlovakiaDepartment of Biotechnology, Delft University of Technology, Delft, NetherlandsAxxence Slovakia s.r.o, Bratislava, SlovakiaDepartment of Biotechnology, Delft University of Technology, Delft, NetherlandsNon-enantioselective alcohol dehydrogenases (ADHs) are rarely found in the biocatalysis portfolio. Generally, highly enantioselective ADHs are sought for. Using such ADHs for the oxidation of racemic alcohols generally results in a kinetic resolution of the starting material, which is unfavourable if the ketone represents the product of interest. In the current contribution we report the ADH from Sphingobium yanoikuyae (SyADH) as non-enantioselective ADH for the complete oxidation or rac-heptan-2-ol (representing further 2-alkanols).https://www.frontiersin.org/articles/10.3389/fctls.2022.926316/fullalcohol dehydrogenasederacemisation reactionsoxidation reactionsbiocatalysisSphingobium yanoikuyae |
| spellingShingle | Eva Puchľová Thomas Hilberath Kvetoslava Vranková Frank Hollmann Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances Frontiers in Catalysis alcohol dehydrogenase deracemisation reactions oxidation reactions biocatalysis Sphingobium yanoikuyae |
| title | Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances |
| title_full | Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances |
| title_fullStr | Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances |
| title_full_unstemmed | Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances |
| title_short | Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances |
| title_sort | towards biocatalytic oxidation of secondary alcohols to carbonyl products of relevance for flavors and fragrances |
| topic | alcohol dehydrogenase deracemisation reactions oxidation reactions biocatalysis Sphingobium yanoikuyae |
| url | https://www.frontiersin.org/articles/10.3389/fctls.2022.926316/full |
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