The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients
Background: Hyperuricemia is well-known as an independent risk factor for the development of hypertension, metabolic syndrome, and cardiovascular disease. Water is essential to most bodily functions, and its consumption rates appear to decline with age. The aim was to evaluate the influence of water...
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MDPI AG
2023-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/3/723 |
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| author | Alma Čypienė Silvija Gimžauskaitė Egidija Rinkūnienė Eugenijus Jasiūnas Rita Rugienė Edita Kazėnaitė Ligita Ryliškytė Jolita Badarienė |
| author_facet | Alma Čypienė Silvija Gimžauskaitė Egidija Rinkūnienė Eugenijus Jasiūnas Rita Rugienė Edita Kazėnaitė Ligita Ryliškytė Jolita Badarienė |
| author_sort | Alma Čypienė |
| collection | DOAJ |
| description | Background: Hyperuricemia is well-known as an independent risk factor for the development of hypertension, metabolic syndrome, and cardiovascular disease. Water is essential to most bodily functions, and its consumption rates appear to decline with age. The aim was to evaluate the influence of water intake on early vascular aging in metabolic middle-aged patients with hyperuricemia. Materials and Methods: The study included 241 men aged 40–55 years and 420 women aged 50–65 years from the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program. Anthropometric characteristics, blood pressure, laboratory testing, and the specialized nutrition profile questionnaire were evaluated. Carotid-femoral pulse wave velocity (cfPWV), assessed using applanation tonometry, was evaluated as an early vascular aging parameter in patients with hyperuricemia and with normal serum uric acid (sUA) levels. Results: 72.6% of men and 83.1% of women drink insufficient amounts of water (less than 1.5 L per day). However, our results showed statistically significant relationships only among a group of women. The women in the hyperuricemic group had a higher cfPWV than women with normal sUA levels. In hyperuricemic women, drinking less than 0.5 L per day in combination with other risk factors, such as age, increasing fasting glucose, and systolic blood pressure, was statistically significantly associated with an increased cfPWV (R<sup>2</sup> = 0.45, Adj. R<sup>2</sup> = 0.42, <i>p</i> < 0.001). Conclusion: Drinking an insufficient amount of water daily is associated with increased arterial stiffness and has a negative effect on vascular health in metabolic women with hyperuricemia. |
| first_indexed | 2024-03-11T09:30:39Z |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T09:30:39Z |
| publishDate | 2023-01-01 |
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| series | Nutrients |
| spelling | doaj.art-a208e5fe57a24aba83f0f8e3581ec5c92023-11-16T17:41:00ZengMDPI AGNutrients2072-66432023-01-0115372310.3390/nu15030723The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic PatientsAlma Čypienė0Silvija Gimžauskaitė1Egidija Rinkūnienė2Eugenijus Jasiūnas3Rita Rugienė4Edita Kazėnaitė5Ligita Ryliškytė6Jolita Badarienė7State Research Institute Centre for Innovative Medicine, 08406 Vilnius, LithuaniaFaculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaFaculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaCenter of Informatics and Development, Vilnius University Hospital Santaros Klinikos, 08661 Vilnius, LithuaniaState Research Institute Centre for Innovative Medicine, 08406 Vilnius, LithuaniaFaculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaFaculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaFaculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaBackground: Hyperuricemia is well-known as an independent risk factor for the development of hypertension, metabolic syndrome, and cardiovascular disease. Water is essential to most bodily functions, and its consumption rates appear to decline with age. The aim was to evaluate the influence of water intake on early vascular aging in metabolic middle-aged patients with hyperuricemia. Materials and Methods: The study included 241 men aged 40–55 years and 420 women aged 50–65 years from the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program. Anthropometric characteristics, blood pressure, laboratory testing, and the specialized nutrition profile questionnaire were evaluated. Carotid-femoral pulse wave velocity (cfPWV), assessed using applanation tonometry, was evaluated as an early vascular aging parameter in patients with hyperuricemia and with normal serum uric acid (sUA) levels. Results: 72.6% of men and 83.1% of women drink insufficient amounts of water (less than 1.5 L per day). However, our results showed statistically significant relationships only among a group of women. The women in the hyperuricemic group had a higher cfPWV than women with normal sUA levels. In hyperuricemic women, drinking less than 0.5 L per day in combination with other risk factors, such as age, increasing fasting glucose, and systolic blood pressure, was statistically significantly associated with an increased cfPWV (R<sup>2</sup> = 0.45, Adj. R<sup>2</sup> = 0.42, <i>p</i> < 0.001). Conclusion: Drinking an insufficient amount of water daily is associated with increased arterial stiffness and has a negative effect on vascular health in metabolic women with hyperuricemia.https://www.mdpi.com/2072-6643/15/3/723hyperuricemiaserum uric acidwater intakecarotid-femoral pulse wave velocitycardiovascular diseasemetabolic syndrome |
| spellingShingle | Alma Čypienė Silvija Gimžauskaitė Egidija Rinkūnienė Eugenijus Jasiūnas Rita Rugienė Edita Kazėnaitė Ligita Ryliškytė Jolita Badarienė The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients Nutrients hyperuricemia serum uric acid water intake carotid-femoral pulse wave velocity cardiovascular disease metabolic syndrome |
| title | The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients |
| title_full | The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients |
| title_fullStr | The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients |
| title_full_unstemmed | The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients |
| title_short | The Association between Water Consumption and Hyperuricemia and Its Relation with Early Arterial Aging in Middle-Aged Lithuanian Metabolic Patients |
| title_sort | association between water consumption and hyperuricemia and its relation with early arterial aging in middle aged lithuanian metabolic patients |
| topic | hyperuricemia serum uric acid water intake carotid-femoral pulse wave velocity cardiovascular disease metabolic syndrome |
| url | https://www.mdpi.com/2072-6643/15/3/723 |
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